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True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair

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Academic year: 2021

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Figure 1: Three disorders for nine genes. Mutations in ten genes are responsible for the xeroderma pigmentosum (XP), the trichothyodystrophy (TTD) or the Cockayne syndrome (CS)
Figure 2: The two subpathways of mammalian NER. Physical or chemical agents like UV, cis-platin, or benzopyrene can damage DNA and induce damage-mediated helix distortions anywhere in the genome (GG-NER in green, bottom panel) or on the transcribed strand
Table 1: Repair/transcription factors and their functions.
Figure 3: NER factors and gene transcription. Upon gene activation, the formation of preinitiation complex (PIC) precedes the recruitment of XPC, which allows the sequential arrival of the other NER factors in the following order CSB, XPA/RPA, XPG/ERCC1-XP
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