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Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium

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HAL Id: tel-00452680

https://tel.archives-ouvertes.fr/tel-00452680

Submitted on 2 Feb 2010

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Rôle des récepteurs Toll-like et de CD14 dans la réponse

à Listeria monocytogenes et à la flagelline extraite de

Salmonella typhimurium

Laure Janot

To cite this version:

Laure Janot. Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium. Sciences agricoles. Université d’Orléans, 2009. Français. �NNT : 2009ORLE2014�. �tel-00452680�

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UNIVERSITÉ D’ORLÉANS

ÉCOLE DOCTORALE SCIENCES ET TECHNOLOGIES

LABORATOIRE d’IMMUNOLOGIE ET d’EMBRYOLOGIE MOLECULAIRE

THÈSE

présentée par :

Laure JANOT

soutenue le : 18 février 2009

pour obtenir le grade de :

Docteur de l’université d’Orléans

Discipline/ Spécialité

: Biologie cellulaire et moléculaire/Immunologie

Rôle des récepteurs Toll-like et de CD14 dans la réponse à

Listeria monocytogenes et à la flagelline extraite de

Salmonella typhimurium

THÈSE dirigée par :

Dr. François Erard Professeur, Université des Sciences d’Orléans

Dr. Bernard Ryffel Directeur de recherche, UMR 6218 Orléans

RAPPORTEURS :

Dr. Irène Garcia-Gabay Chargée de cours, Université de Genève

Dr. Dominique Buzoni-Gatel Directrice de recherche, INRA de Tours

_____________________________________________________________________

JURY

Dr. Pascale Cossart Directrice de recherche, Institut Pasteur Paris

Dr. Irène Garcia-Gabay Chargée de cours, Université de Genève

Dr. Dominique Buzoni-Gatel Directrice de recherche, INRA de Tours Dr. Jean-Claude Sirard Chargé de recherche, INSERM U801 Lille

Dr. François Erard Professeur, Université des Sciences d’Orléans

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Figure

Figure 2. Reduced resistance of CD14-deficient ( 2 / 2 ) mice infected with Listeria monocytogenes
Figure 1. Impaired soluble TNF but normal IL-12p40, nitrite production, and killing of LM by macrophages from mem-TNF mice
Figure 2. Enhanced control of LM infection in mem-TNF mice compared to TNF-deficient mice
Figure 3. Numerous but confined, smaller hepatic microabscesses in mem-TNF mice compared to TNF-deficient mice
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