Tracking stressed blood volume during vascular filling experiments

(1)

A.#Pironet

1

_{,#P.#C.#Dauby}

1

_{,#J.#G.#Chase}

2

_,#S.#Kamoi

2

_,#N.#Janssen

1

_{,#P.#Morimont}

1

_,#T.#Desaive

1

_#

TRACKING#STRESSED#BLOOD#VOLUME##

DURING#VASCULAR#FILLING#EXPERIMENTS#

Introduc)on*

Methods*

•  Vascular*filling*is*a*common*procedure*to*restore*cardiac*output*(CO)*in*cri)cally*ill*pa)ents*.* •  Total*stressed*blood*volume*(SBV)*is*defined*as*the*total*pressureAgenera)ng*blood*volume.* •  SBV*has*been*associated*with*success*or*failure*of*vascular*filling*therapy*.* •  Current*methods*to*determine*SBV*involve*repeated*phases*of*circulatory*arrests*followed*by*fluid*infusion,*which* is*)meAconsuming*and*can*be*harmful*.* •  In*this*work,*a*modelAbased*method*is*developed*to*track*SBV*during*vascular*filling*experiments.*

Results*

Reference*

*Maas,*J.*et*al.*Bedside*Assessment*of*Total* Systemic* Vascular* Compliance,* Stressed* Volume* and* Cardiac* Func)ons* Curves* in* Intensive* Care* Unit* Pa)ents.* Anesthesia* &*

Analgesia,*115(4),*880A887,*2012.**

Acknowledgments*

A.Pironet@ulg.ac.be*

Contact*

#

1

_{UniversityofLiège(ULg),GIGAACardiovascularSciences,Liège,Belgium}

2

_{DepartmentofMechanicalEngineering,UniversityofCanterbury,NewZealand*}

The*parameters*of*a*3Achamber*cardiovascular* system*model*were*adjusted*to*fit*the*data.* LeF*ventricular,*aor)c,*and*vena*cava*pressures*and*leF*ventricular* volume*were*recorded*before*and*aFer*each*infusion.** Vascular*filling*experiments* (successive*infusions*of*saline* solu)on)*were*performed*on*6*pigs:* •  pigs*1*and*2*received** 500*ml*infusions* •  pigs*3*to*6*received** 225*ml*infusions.* •  SBV*is*associated*with*the*change*in*CO*following*fluid*infusion.* •  The*response*curves*are*subjectAspecific.*

Conclusions*

The*SBV*value*is*associated*with*the*change*in*CO*aFer*each*500/225*ml*ﬂuid*infusion,*as*previously*no)ced*.* SBV* Heart* Veins* E_h(t)* E_a* R_i* R_o* R_v* E_v* Arteries* –15* –10* –5* 0* 5* 10* 20* 15* Ch an ge *in *C O *aF er *ﬂ ui d* in fu si on *(m l/ s) * 150* 50* 150* 225* 300* 100* 200* 300* 1000* 2000* 3000* 1000* 2000* 3000* 2500* 3500* 4500*

Pig*1* Pig*2* Pig*3* Pig*4* Pig*5* Pig*6*

SBV*(ml)* SBV*(ml)* SBV*(ml)* SBV*(ml)* SBV*(ml)* SBV*(ml)* 100* 1* 4*2* 3* 1* 1* 1* 1* 1* 2* 2* 2* 2* 2* 3* 3* 3* 3* 4* _4* 5* D* 4* 5* 4* 5*