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3D finite element formulation for mechanical-electrophysiological coupling in axonopathy

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Figure 1: Axonal membrane outward current flux, a) either impeded by myelin layers in the internodal regions, b) or governed by the dynamics of the gating of the N a V and K V channels in the nodes of Ranvier, modelled by the CT and HH models, respectively
Figure 2: Deformation of a rat F11 cell under substrate stretch simulated by pressure boundary conditions applied to the lateral sides of the cytoplasm domain.
Table 1: Electrophysiological parameter values.
Figure 3 presents the mean normalised current of a patch under whole cell voltage clamp at 0 mV for the control cells (blue line) and stretched cells (red line)
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