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4SC-101, A Novel Small Molecule Dihydroorotate Dehydrogenase Inhibitor, Suppresses Systemic Lupus Erythematosus in MRL-(Fas)lpr Mice

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Academic year: 2021

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Figure 1. Structure and biochemistry of 4SC-101. 4SC-101, 2-(3-fluoro-3⬘-me- 2-(3-fluoro-3⬘-me-thoxybiphenyl-4-carbamoyl)-cyclopent-1-enecarboxylic acid, is a novel inhibitor of human DHODH discovered by molecular design based on the X-ray structure of hum
Table 1. Pharmacodynamics of 4SC-101
Figure 3. 4SC-101 reduces systemic autoimmunity in MRL lpr/lpr mice. A: Mesenteric lymph node weight was determined at 22 weeks after ten weeks of vehicle, 4SC-101, or CYC treatment
Figure 4. 4SC-101 improves renal histopathology in MRL lpr/lpr mice. A: Renal sections of 22-week-old MRL lpr/lpr mice were stained with periodic acid Schiff and antibodies for IgG and CD3 (T cells) as indicated
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