Abstract of oral communication
ICBCBBE 2013 Amsterdam, may 15-16 2013
Pauline SAINVITU CBI – CBMN, GxABT, ULg
Biophysical characterization of the interaction of novel
aromatic glycolipid surfactants with membrane models.
P. Sainvitu P. Sainvitu P. Sainvitu
P. Sainvitu a,ba,ba,ba,b, K. Nott , K. Nott , K. Nott , K. Nott a,ca,ca,ca,c, F. Nicks, F. Nicks, F. Nicks, F. Nicks a,ca,ca,ca,c, P. Laurent, P. Laurent, P. Laurent, P. Laurent a,c a,ca,ca,c, L. Willems , L. Willems , L. Willems , L. Willems dddd, J.----P. Cosse , J., J., J.P. Cosse P. Cosse P. Cosse dddd, , , ,
J. J. J.
J.----M. Crowet M. Crowet M. Crowet M. Crowet bbbb, L. Lins , L. Lins , L. Lins , L. Lins bbbb, C. Jérôme , C. Jérôme , C. Jérôme , C. Jérôme eeee, M. Deleu, M. Deleu, M. Deleu, M. Deleu a,ba,ba,ba,b....
a Department of Industrial and Biological Chemistry, b Centre de Biophysique Moléculaire Numérique, c
Department of General and Organic Chemistry, d Molecular and Cellular Biology Lab, Gembloux
Agro-Bio Tech, University of Liege, Belgium, e Center for Education and Research on Macromolecules,
University of Liege, Belgium
Keywords: Aromatic glycolipids, monolayer models, membrane models, antioxidant
Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells.
In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group.
Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed.
