Th-232(d,4n)Pa-230 cross section measurements at ARRONAX facility

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Th-232(d,4n)Pa-230 cross section measurements at ARRONAX facility

Arnaud Guertin, Charlotte Duchemin, Ferid Haddad, N. Michel, Vincent Métivier

To cite this version:

Arnaud Guertin, Charlotte Duchemin, Ferid Haddad, N. Michel, Vincent Métivier. Th-232(d,4n)Pa-230 cross section measurements at ARRONAX facility. International Conference on Nuclear Data for Science and Technology 2013, Mar 2013, New-York, United States. �in2p3-01955640�

232

_{Th (d, 4n)}

230

_{Pa cross section}

measurements at ARRONAX facility

Nuclear Data for Science and Technology 2013

New York USA

Session HD Cross Section Measurements

GUERTIN Arnaud

SUBATECH Laboratory CNRS Research Officer

Outline

 Motivations

 Experimental set-up and data measurements

 Results and comparisons

Motivations

Innovative radionuclides: PET imaging, β- _and α targeted radiotherapy α RIT: binding an α emitter to an antibody to target and destroy tumor cells

ᴥ high LET ᴥ important cytotoxic effect ᴥ minimizing damage

226_{Th: novel therapeutic nuclide, a more potent} α emitter for leukemia than 213_{Bi (46 min)}

ᴥ decay: 4 α cascade, 27.7 MeV ᴥ generator system: 230_{U(21 d)/}226_{Th(31 min)} Production routes: 231_Pa(p,2n)230_U 232_Th(p,3n)230Pa → 230_U 232_Th(d,4n)230Pa → 230_U

Outline

 Motivations

 Experimental set-up and data measurements

 Results and comparisons

Experimental set-up and data measurements

Th

Ti

Al

Stacked-foil technique:

- target / monitor / degrader pattern - thin foils

Activity and cross section: σ = Act . A Φ . 𝒩𝒩_A . ρ . e . (1 − e−λ.t₎ σ = σ′. Act . A . ρ′ . e′ . (1 − e−λ ′_.t ) Act′ . A′ . ρ . e . (1 − e−λ.t₎

Use of a monitor foil:

 error on e, e’: ≤ 1%  error on t: negligible

IAEA recommended cross sections:

- 5 reactions available for deuteron beam  27_{Al (2),} nat_{Fe (1),} nat_{Ni (1) and}

- nat_Ti(d,x)48_V

 error on σ: ≤ 12%

Capsule and foils

Nice III and beam line

Stacked-foil set-up

- deuteron beam: 22 and 30 MeV - intensity: 100 nA - irradiation time: 30 min

Data measurements

- HPGe coaxial detector - γ spectra recorded on 8192 channels - Dead time: < 10% (sum peak) - FWHM:1.04 keV at 122 keV (57_Co)

- Activity values: FitzPeaks 1.97 keV at 1332 keV (60_Co)

- T_1/2, E_γ, I_γ: Lund/LBNL, NNDC - Energy and efficiency calibrations : Co and Eu - Target and monitor:

 counted twice  during > 24 hrs  2 week delay

Outline

 Motivations

 Experimental set-up and data measurements

 Results and comparisons

Results and comparisons

- TALYS 1.4, default parameters

- Very low cross sections, far from the experimental data

- Eγ 312.17 keV Iγ 38.6%

- Eγ 312 keV Iγ 37%

- Threshold: 0.0 MeV - 233_{Pa: T}

1/2 = 26.967 d

- Same trend

Results and comparisons

- TALYS 1.4, default parameters - Threshold: 3.537 MeV - 232_{Pa: T} 1/2 = 1.31 d - Eγ 969.315 keV Iγ 42.3% (228_{Ac I}γ 15.8%) - Eγ 894 keV Iγ 22%

(Pb X ray 75 keV + 136_{Cs 819 keV)}

- Same trend

Results and comparisons

- Threshold: 16.014 MeV - 230_{Pa: T}

1/2 = 17.4 d - Eγ 951.95 keV Iγ 29.1%

- Eγ 952 keV Iγ 28%

- TALYS 1.4, default parameters

- Neither the shape nor the maximum value are reproduced

- Same trend but a small energy shift and a maximum value slightly higher - Difference not explained by the Iγ update in database since 1986

Outline

 Motivations

 Experimental set-up and data measurements

 Results and comparisons

Conclusions and outlooks

 New data sets obtained: 232_Th(d,xn)230,232,233_Pa

- compared with J. Rama Rao et al.

 232,233_{Pa: same trends, influence of the branching ratio values}

 230_{Pa: same trend, higher amplitude, shift in energy}

- compared with TALYS calculations

 default parameters, no satisfactory results

 Also new data sets extracted from the monitors: nat_Ti(d,x)43,44,44m,46,47,48_Sc Outlooks:

 Yield estimation in Bq/A.h  Production route comparison:

- yields - contaminants - chemistry  TALYS parameter tuning:

- optical models (5) - level density models (5) - pre-equilibrium models (4)

Innovative radio-isotope program for PET imaging, β- _and α targeted radiotherapy

Thank you for your attention

Nuclear Data 2013, Session HB

Acknowledgments to the ND 2013 organization committee

232_Th(d,4n)230_{Pa cross-section measurements}

C.Duchemin,1 _A.Guertin,1 _F.Haddad,1, 2 _N.Michel,2 _{and V.Metivier}1

1_{SUBATECH, Ecole des Mines de Nantes, Université de Nantes, CNRS/IN2P3, Nantes, France}

2_{GIP Arronax, 1 rue Aronnax, 44817 Saint-Herblain, France}

The ARRONAX cyclotron is a project promoted by the Regional Council of Pays de la Loire financed by local authorities, the French government and the European Union