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The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.

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Academic year: 2021

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Fig. 1. Obtaining Octarellin V.1 by directed evolution. a) GFP-based screening for soluble mutants was used through 8 rounds of directed evolution; the best clone of each round is shown
Fig. 5. Automated structure prediction tools evaluated using Octarrelin V.1. a) GDT_TS evaluation of the different models

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