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Switch: pilot intervention that targets motivational deficits in people with schizophrenia

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Switch: pilot intervention that

targets motivational deficits

in people with schizophrenia

Thonon, B.

a

*, Levaux, M.-N.

b

, Larøi, F.

a,c,d

*benedicte.thonon@uliege.be

Background

__________________

Methods

____________

9 participants with schizophrenia / schizoaffective

disorder participated in Switch for 6 months. 7 of

them followed Switch for 12 months.

T0

T1

T2

T3

(6m, +- 20 sessions) (12m, +- 30 sessions) 18m

n=14 n=9 n=7

Assessement (T0-T3):

•Brief Negative Symptom Scale (BNSS)

Amotivation subscale

•Functional Remission of General Schizophrenia (FROGS)

•Schizophrenia - Quality of Life scale (S-QOL)

Results and Discussion

______________________________

a Psychology and Neuroscience of Cognition Research Unit, Université de Liège, Belgium. b Intercommunale de Soins Spécialisés de Liège, Belgium. c Department of Biological and Medical Psychology, University of Bergen, Norway. d NORMENT – Norwegian Center of Excellence for Mental Disorders Research, University of Oslo, Norway.

References and additional information: benedicte.thonon@uliege.be

= Best predictors (Fervaha et al., 2015)

= Resistant to pharmaceutical treatment

(Chue and Lalonde, 2014)

= Target of only a few interventions

(Lincoln and Pedersen, 2019)

Ø Goal

____________

Difficulties in daily

functioning

Low quality of life

Negative symptoms

Motivational

deficits

People with

schizophrenia

45’ / week 0-6 months 45’ / 2 weeks 6-9 months 45’ / 3-4 weeks 9-12 months

-Develop + validate a multifactorial intervention

based on models of motivational deficits in

schizophrenia

(Kring and Barch, 2014; Rector et al., 2005)

1,5 2,0 2,5 3,0 3,5 4,0 0 1 2 3

Paired sample t-tests

Comparing T1, T2, T3 to T0

Mean scores

BNSS Amotivation S-QOL FROGS M

*

* p < .10 ** p < .05

**

**

• After 6 months of Switch, significant and important reduction in motivational deficits (d=-0.98, p=.02) and functional outcomes (d-0.90, p=.04).

• After 12 months of Switch, significant and important reduction in motivational deficits (d=-0.90, p=0.05). Moderate improvement on functional outcomes, but statistically non-significant (d=0.42,

p=.30).

• 6 months after the end of Switch, moderate reduction in motivational deficits (d=-0.50, p=.23) and functional outcomes (d=0.66, p=.17), but statistically non-significant.

• Zero effect on reported quality of life. Secondary analyses: improvement on satisfaction regarding family relationships.

Ø Moderate to moderately severe motivational negative

symptoms became light to moderate. Participants in Switch

showed more autonomy in their daily life after the intervention.

Ø Need to work on the maintenance of the improvement and the

Références

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