• Aucun résultat trouvé

Les cellules souches du tissu adipeux : état de l’art et perspectives en odonto-stomatologie

N/A
N/A
Protected

Academic year: 2021

Partager "Les cellules souches du tissu adipeux : état de l’art et perspectives en odonto-stomatologie"

Copied!
108
0
0

Texte intégral

(1)Les cellules souches du tissu adipeux : état de l’art et perspectives en odonto-stomatologie Nathan Touret. To cite this version: Nathan Touret. Les cellules souches du tissu adipeux : état de l’art et perspectives en odontostomatologie. Médecine humaine et pathologie. 2015. �dumas-01467126�. HAL Id: dumas-01467126 https://dumas.ccsd.cnrs.fr/dumas-01467126 Submitted on 21 Feb 2017. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2)    X P        y{5$-4$#$2( !+$2+$42W w}z|~("$$#$7w{.    .        R  P    . --@$ywx|. '?2$-ˆ{yZ|~Zx|Zx{.   . . 1@2$-3@$$32.43$-4$/4!+(04$,$-3#$5 -3  "4+3@#$'(141&($\$-3 (1$#$("$ . $, 1#(€)4(-ywx| .  1 . /.3)%52!4(!. . @+$yx .L3x€€:("$ .  .41.!3$-(1+$&1 #$#$ #$#$YY.     h(/+H,$#`3 3i        .   1 . )(-#/,&,) --/, )(-#/,&)./, '&)./, )(-#/,&)./, )(-#/,&)./,. .,#%  0-   ",#-.#(  ),(  &2 . ,8-#(./$/,3 ----/, ----/, #,./,."7- ',#(0#.8  .

(3)   . . . **1'/*(0',-(.%(,'  .    . 2)'-'&.(+*"  "  . +/--'&.(+*  ! ,*"!--!/, !-)%0!,-%.2-(! %$3'! 4.,! !*)"2,!)!- !-)%0!,-%.2-(! 

(4) ', --%-.).

(5) *-+%.'%!,)%0!,-%.%,!(!  ,%3'! +/--'&.(+*   ,*"!--!/, !-)%0!,-%.2-(!   ,(!''! 4.,! !*)"2,!)!- !-)%0!,-%.2- %!,,! --%-.).

(6) *-+%.'%!,)%0!,-%.%,!(! ,*'%)! --%-.).

(7) *-+%.'%!,)%0!,-%.%,!(!#*5 +/--'&.(+*"    ,*"!--!/, !-)%0!,-%.2-(!   /,!)! --%-.).

(8) *-+%.'%!,)%0!,-%.%,!(!

(9) 2'%)! .

(10) 2)'-'&.(+*! !! . +/--'&.(+*  4.,! !*)"2,!)!- !-)%0!,-%.2-

(11)  0!- 4.,! !*)"2,!)!- !-)%0!,-%.2-(!   20!,%)! --%-.).

(12) *-+%.'%!,)%0!,-%.%,!  2,6(! --%-.).

(13) *-+%.'%!,)%0!,-%.%,!(! /'%! +/--'&.(+*!!   ! !     4.,! !*)"2,!)!- !-)%0!,-%.2-

(14)  .,%! 4.,! !*)"2,!)!- !-)%0!,-%.2-

(15)  !)'/ ! --%-.).

(16) *-+%.'%!,)%0!,-%.%,! 

(17) *, ) --%-.).

(18) *-+%.'%!,)%0!,-%.%,!  $,'!- +/--'&.(+*! ,*"!--!/, !-)%0!,-%.2-(! 

(19)  -!''! 4.,! !*)"2,!)!- !-)%0!,-%.2-(!

(20) 2'3)! 4.,! !*)"2,!)!- !-)%0!,-%.2-(!

(21) $,%-.%)! . 2)'-'&.(+*#! #! !   ! . +/--'&.(+* "   ,*"!--!/, !-)%0!,-%.2-(! ,%! ,)! ,*"!--!/, !-)%0!,-%.2-!)/' ,*"!--!/, !-)%0!,-%.2-    .%!))! 4.,! !*)"2,!)!- !-)%0!,-%.2-(!

(22) .$'%! --%-.).

(23) *-+%.'%!,)%0!,-%.%,!(! 

(24)  !'+$%)! --%-.).

(25) *-+%.'%!,)%0!,-%.%,!  2(% --%-.).

(26) *-+%.'%!,)%0!,-%.%,! *(%) +/--'&.(+*  ,*"!--!/, !-)%0!,-%.2-(!'%,! 4.,! !*)"2,!)!- !-)%0!,-%.2-0!- 4.,! !*)"2,!)!- !-)%0!,-%.2-(!  '2,%! 4.,! !*)"2,!)!- !-)%0!,-%.2-

(27) '%0%!, --%-.).

(28) *-+%.'%!,)%0!,-%.%,!(!   2*)*, --%-.).

(29) *-+%.'%!,)%0!,-%.%,!(! /,!)! --%-.).

(30) *-+%.'%!,)%0!,-%.%,! ).*%)! --%-.).

(31) *-+%.'%!,)%0!,-%.%,!!) /1 +/--'&.(+* ! #! ,*"!--!/, !-)%0!,-%.2-, ,*"!--!/, !-)%0!,-%.2-

(32)  .,%& 4.,! !*)"2,!)!- !-)%0!,-%.2-    ,% 4.,! !*)"2,!)!- !-)%0!,-%.2-(!

(33)  '* %! --%-.).

(34) *-+%.'%!,)%0!,-%.%,!(! 2)2 %.!.      Y `    .  .

(35)   .                          .      .      Y `    . .

(36)    .       41@2(#$-3#4 418W      . /.3)%52,%2/&%33%52!42)#+ MM ."3$41$-'(141&($$-3 (1$W 1.%$22$41#$2-(5$12(3@2f1 3("($- .2/(3 +($1W .42\2$"3(.-#$2"($-"$2- 3.,(04$2$3'82(.+.&(04$2W -"($-'$%#4H+$#`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`    . .

(37)    .       ,.-(1$"3$41#$'?2$W    .  . /.3)%52,%/#4%52/2$!. MM  ."3$41$-'(141&($$-3 (1$W 22(23 -3 .2/(3 +($1-(5$12(3 (1$f1 3("($- .2/(3 +($1W .42\2$"3(.-#$'(141&($4"" +$W 3'.+.&($$3'@1 /$43(04$W-$23'@2($$3@ -(, 3(.-Z.   -/#-.,7--(-#&5&I")((/,+/0)/-'I04 #.(*.(.#,#!,.,0#&G I2&&(+/0)/-,","4)(-.''(.(-0).,*,.#+/+/).##(( #.0)/-/( 2'*&5-/#0,G)/./&)(!')(/,-/-D$I#*/**,8#,0).,*8!)!#.0).,,#!//, #(.&&./&&G  )( #(+/0)/-'I04),8*)/,.,#.,-/$.'.)/".'I")(),G  ,#*)/,0).,,!,5& )#-,#.#+/.#(0#&&(.+/#'I*,'#-D$&I-*7,D )/,(#,/( .,0#&+/&#.8G . . )34--/,8'-#(7,)(-#8,.#)(.')(*,) )(,-*.G.      Y `    . .

(38)    .      47,$,!1$2#4)418W        . /.3)%52,%/#4%526%3  MM  ."3$41$-'(141&($$-3 (1$W  D31$#$.-%@1$-"$#$2-(5$12(3@2f1 3("($- .2/(3 +($1W $2/.-2 !+$#$+ 2.42\2$"3(.-#$ 1.#.-3.+.&($ .       

(39)  

(40)      

(41)     -*)(.(8'(.  $/!,  .,0#&G  ).,*,8-(($)/,-#-3')&#+/'.(#.5=/,DI),*,+/$I'#,-#(7,'(. &I(-#!((. *--#)((8 +/ 0)/- 9.-D (-/#. *, +/ 0)., /.),#.8 . 0)., 2*8,#( ,)((/- ),(. .)/. ' )(-#8,.#)(D ( #( *, +/ 0)., "/')/, . 0)., "&/, -)(. ",-5&#'(-#)()(0#0#&+/$-)/"#.#-)((,5&*,8-(..#)(.,0#&G  /#&&4,)#,('*,) )(,)((#--(.3.,)/0,&.8')#!(!.)/.')(-.#'G.  .      Y `    . .

(42)    .              . !$!-%,%/#4%52(2)34).% MM  ."3$41$-'(141&($$-3 (1$W  D31$#$.-%@1$-"$#$2-(5$12(3@2f1 3("($- .2/(3 +($1 .42\2$"3(.-#$2"($-"$2(.+.&(04$2  . -/#-.,7-")(),8+/0)/-34*.8-#8!,(-')($/,3."7-G  I#/&*,#0#&7!I**,8#,0)-)'*8.(-D0).,#-*)(##&#.8.0).,!(.#&&--/)/,- ' ),'.#)(G)/-'I04 #.*,.0).,-0)#,.0).,2*8,#((-&,8"#&#..#)(  & 0#.8 ),&D &I)'*!('(. . & -/#0# - *.#(.- 3(. -/# /( "#,/,!# ,#()&)!#+/,0#)H #&G  )34--/,8'!,.#./.')(*,) )(,-*.G  . . . .      Y `    . .

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`    .  .

(44)    . !$9M  (#$#(-&4$Z.      Y `    .  . .

(45)    . -%3!2%.43M;-%32>2%3M , 3@31 +.&($#4.-'$41W"$).41$23+$5H31$Z.      Y `    .  . .

(46)    . -%32!.$P0!2%.43M,%8%4 5#%44%M  /8+$79 ``+-.42, -04$W .42A3$2+$2/(+($12#$, 5($W:) , (2# -2,.-"J41Z.      Y `    . .

(47)    . -%32!.$3P0!2%.43M$-/.$%4!2)%M 5$"3.43$, 3$-#1$22$$3,.- #,(1 3(.-Z.      Y `    . .

(48)    . -%3"%!58P0!2%.43M;-%3"%,,%3P3C523M 04(#`$,!+@$,`.-3 ""4$(++(".,,$4-%(+2$34-%1?1$Z.      Y `    .  .

(49)    . -!&!-),,%M 5$"3.43,.- ,.41Z.      Y `    .  . .

(50)    . ,!!#5,4?M;-%3-!@42%3M -&1 -#,$1"(/.415.2".,/@3$-"$2$3+ 1("'$22$#$5.2$-2$(&-$,$-32Z. -!02/-/4)/.M $1"(/.413.42"$2,.,$-32Z.      Y `    .  . .

(51)    . -%3!-)3M 3.42"$4704(,$2.-3"'$12Z.      Y `    .   .

(52)   .            .         R          P       .      Y `    .  .

(53)    .   .  OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO.   .  OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOae  . POOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOd  .  OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOe  . O     OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOg . O O O O.        !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!*       !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!+   R U V!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!#"    !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!##.  . O R      OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOab . O      !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!#% O   ^      !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!#& O  ^      !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!#'.  . O   M   OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOba . O O O O O O.    

(54)     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!$$ 

(55) .    !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!$&        !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!$'   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!$'     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!$(    M      N!!!!!!!!!!!!!!!!!!!!!!!!!!$+.  . O      OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOca . O O O O O O O O. O O.  !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!%$        !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!%%  P  YZ!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!%%   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!%'  R    !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!%(        !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&".  !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&#   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&$  !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&%    !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&&. .      Y `    . >.

(56)    .     O      P OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOde . O  !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&( O    N     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!&).  .  O     P OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOdh . O O O O O O O O. O.   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!'"   R !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!')   R   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!(#     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!(%    !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!('      !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!()    P  !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!(+     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)# .     !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)$.  . . O     OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOgc . O O O O O. M       !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)%       !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)&       !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)'       !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)'   !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)'.  .   OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOgf   .    OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOgh  . R OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOhi  .  OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOi`.      Y `    . ?.

(57) .   .    . .         c'$.18(26'$-6$*-.6$5$183'(-&!43-.3'(-&6.1*2Z  1 7(2(26'$-$5$183'(-&6.1*2!436$#.-.3*-.66'8Z  $ +6 82$-#4/!8".,!(-(-&3'$.186(3'/1 7(2Y-.3'(-&6.1*2 -#6$#. -.3*-.66'8Zd .      . %!(*  .      Y `    . @.

(58)   .       .  .      Y `    . A.

(59)    .  . - ++(& 3.1/$431$-.45$+$12$2#$-32)4204`:"(-04 -3$%.(2x\yZ3,($4704$+ 04$4$ #4 +@9 1#W +  2 + , -#1$  +  " / "(3@ #$ 1@&@-@1$1 (-3@&1 +$,$-3 4- ,$,!1$ ,/43@ .4 4- .1& -$/ 13($++$,$-3#@314(3z]  ` .,,$W04 -3:+4(W! (&-$# -2+ 2"($-"$%("3(.-#$/4(2!($-+.-&3$,/2$-2`(,/+ -3 -3#$2 ".1/2 @31 -&$12W 04`(+ 04 +(%($ #$ c!(.".,/ 3(!+$2dW ".,,$ ,.8$- #$ 1$,/+ "$,$-3 #$ 2$2 .1& -$2#@%$"34$47Z.42#$5$-.-2#$2"1@ 341$2"8!.1&$3+$2$-% -32#$#$, (-1@".+3$1.-3 #$2".04(++ &$2.4#$2(,/+ -32#$-3 (1$2241-.2/+ &$2Z  $/$-# -3 +  1@&@-@1 3(.- #$ +`.1& -$ /$1#4  3.4).412 $7$1"@ 4-$ /1.%.-#$ % 2"(- 3(.- 4 /.(-3 #`(-2/(1$1 #$ -.,!1$47 ,83'$2W / 1%.(2 31?2 -"($-2W 3$+2 04$ +$ %.($ #$ 1.,@3'@$ h+$ /1@5.8 -3i 04( 1$/.422 (3 "' 04$ , 3(-W /4(204$ +` (&+$ #4  4" 2$ +$ +4( #@5.1 (3 3.43$2 +$2 -4(32{Z$11(?1$"$#@2(1#$1@&@-@1 3(.-/.411 (3!($-2$#(22(,4+$14-$2/.(1#`(,,.13 +(3@Z  5 -3#` 33$(-#1$+`(,,.13 +(3@W-.31$ ,!(3(.-W/+42,.#$23$W2$1 (3#$/1./.2$1:Z4/.-3W + 1@&@-@1 3(.-#$2$2#@% 432.22$47W/ 1.#.-3 47$3/4+/ (1$2/ 1+`43(+(2 3(.-#$, 3@1( 47 3 ,/.--@2#4+ !$+xwwZ4/.-3]  -$ 3$++$ //1."'$ $23 : +  ! 2$ #$ "$33$ -.45$++$ /$12/$"3(5$ -.,,@$ ,@#$"(-$ 1@&@-@1 31("$.4(-&@-($1($3(224+ (1$Z   ,@#$"(-$ 1@&@-@1 31("$ 1$/.2$ 241 +`43(+(2 3(.- #$ "$++4+$2 2.4"'$2|Z $ 2.-3 #$2 "$++4+$2 " / !+$2#$#.--$1- (22 -"$:#(%%@1$-3238/$2#$"$++4+$22/@"( +(2@$2W04(/.411.-31@/ 1$1 #$23(2242$-#.,, &@2.4, + #$2W/ 14-/1."@#@04$+`.- //$++$+ #(%%@1$-"( 3(.-Z  '$9 +`'.,,$W +$2 "$++4+$2 2.4"'$2 ,@2$-"'8, 3$42$2 +$2 /+42 @34#(@$2 2.-3 +$2 "$++4+$2 231., +$2#$+ ,.$++$.22$42$}Z $4143(+(2 3(.-$23"$/$-# -3".-31 1(@$/ 1+$2#(%%("4+3@2#$ /1@+?5$,$-3$3+$41-.,!1$04(#(,(-4$1 /(#$,$-3 5$"+`<&$Z . +$7(23$-@ -,.(-2#$22(3$2$731 \204$+$33(04$2".,,$+ /$ 4W+ /4+/$#$-3 (1$W+$+(& ,$-3 / 1.#.-3 +.4+$3(224 #(/$47.K+`.-1$31.45$#$2"$++4+$2,4+3(/.3$-3$2~Z  .-&3$,/2".-2(#@1@".,,$4-3(224#@/+ (2 -3$3@" 13@#$+ 1$"'$1"'$W+$3(224 #(/$47$23 $-/' 2$#$#$5$-(1+`@3.(+$,.-3 -3$#$+ ,@#$"(-$1@&@-@1 31("$ $-1 (2.-#$+s !.-# -"$ #$+ 2.41"$#$3(224$3#$2 % "(+(3@#$/1@+?5$,$-3Z $2"$++4+$22.4"'$2,@2$-"'8, 3$42$2 #43(224 #(/$47hi04(1@2(#$-3# -22.-231., .-34-$&1 -#$/+ 23("(3@$3+$41-.,!1$ $23(,/.13 -3$3".-23 -3#41 -3+ 5($Z s.!)$"3(%#$-.31$@34#$2$1 #` - +82$1+s //.13#$2# -2+`(-&@-($1($3(224+ (1$W$3 /+42 / 13("4+(?1$,$-3 # -2 +  1@&@-@1 3(.- #$ 3.43$2 +$2 2314"341$2 #$ +  2/'?1$ .1 +$Y .22$42$W / 1.#.-3 +$W /4+/ (1$W #$-3 (1$W &(-&(5 +$W "(-$42$W "'.-#1 +$ .4 $-".1$ /.23\ 34,.1 +$ %(- #`@3 !+(1 4- /1.3.".+$ "+(-(04$ 2(,/+$W /$1%.1, -3 $3 /$4 ".L3$47 # /3@ +`.#.-3.23., 3.+.&($Z  $04(/ 1 (22 (3% -3 (2(23$$3(-(, &(- !+$ 478$47#$"$13 (-2W     

(60)

(61) 

(62)  33$(&- !+$$3/.411 (31@5.+43(.--$1-.31$/1.%$22(.-]. .      Y `    . B.

(63)   .                          . O     .      Y `    . C.

(64)       . O           -2+ 2/'?1$.1.% "( +$W#$-.,!1$4731 4, 2W/ 3'.+.&($2.4(-%$"3(.-2".-#4(2$-3:#$2/$13$2#$24!23 -"$ .22$42$2W#$-3 (1$2#.-3+ &4@1(2.--`$23/ 22/.-3 -@$Z  $ , 22(% % "( + #(2/.2$ #`4-$ 1"'(3$"341$ 31?2 ".,/+$7$W +4( /$1,$33 -3 : +  %.(2 #` 2241$1 +  5($ 2."( +$€ #4 / 3($-3:31 5$12+ /'.- 3(.-W+`$23'@3(04$#42.41(1$$3+$2$7/1$22(.-2#45(2 &$X+ /1.3$"3(.-#`.1& -$2-.!+$2 ".,,$ +$ "$15$ 4 .4 +$2 8$47 $3 #$2 %.-"3(.-2 5(3 +$2 ".,,$ +  1$2/(1 3(.-W +  , 23(" 3(.- .4 $-".1$ +  #@&+43(3(.-Z  . .43$/$13$#$24!23 -"$(-3@1$22 -3"$2$2/ "$2 41 #.-"4-1$3$-3(22$,$-3(,/.13 -3241+ 5($#4/ 3($-3$3 -@"$22(3$1 4-$3'@1 /$43(04$ # /3@$Z   .  <1      . . .     `.1(&(-$2! "3@1($--$2W2823@,(04$2W  3(04$2W+$2, + #($2#42823?,$ 31 4, #` 33  "'$$-31 (-$-3+`(-%+ ,, 3(.-#$2 3(2242$3+ #$2314"3(.-#$+`.2 .   %4     1($2W1$23 41 3(.-2$331 4, 3(2,$2 "'1.-(04$2,?-$-3:#$2(-%+ ,, 3(.-2 /4+/ (1$2#.-3+ 2 -"3(.-$23+  /4+/$"3.,($.   `.2 +5@.+ (1$$23+$2$4+.2#4".1/2 '4, (-#.-3+`(-5.+43(.-$233.3 +$#?2 +.1204$+`.1& -$04`(+2.43$- (3h+ #$-3i 5($-3:#(2/ 1 D31$Z.      / /$13$#424//.13/ 1.#.-3 +$-31 (-$ 4-$ 4-$#@-4# 3(.-1 #("4+ (1$W:+`.1(&(-$#$ 2$-2(!(+(3@2#$-3(- (1$2 .  P     ` !2$-"$#$" + &$:+`.1(&(-$#`4-$ , 23(" 3(.-4-(+ 3@1 +$/$43$-31 (-$1 4-$4241$/1@, 341@$#$2".-#8+$2 h.23@./'83$2iW04(/$43".-#4(1$:3$1,$ :4-$ 13'1.2$#4".-#8+$.            .               .     -$, 45 (2$1@/ 13(3(.-#$2".-31 (-3$2  $-31$#$2(,/+ -32$3#$2#$-32  - 341$++$2$-31 (-$4-$"1 3@1(2 3(.-#$2  24//.132$-5(1.-- -32   .  5$9\5.4231.45@+` /$71@2(#4$+^.      Y `    . D.

(65)       . O           4 %(+ #$2 --@$2W /.41 1$,@#($1 47 /$13$2 #$ 24!23 -"$2W +  #$-3(23$1($ 2`$23 ! 2@$ 241 +$2 ".-- (22 -"$2 2"($-3(%(04$2# -2+$2#., (-$2#$+ !(.+.&($$3#$2!(., 3@1( 47Z  $231 (3$,$-32#$-3 (1$22$2.-33.43#` !.1#! 2@2241+$2/1(-"(/$2#$+ #)#!42)3!4)/.xwW"`$23:#(1$1$23 41$1+  %.-"3(.- #$2 .1& -$2 2 -2 2$ 2.4"($1 #$ +` 1"'(3$"341$ (-(3( +$ #4 3(224Z  "(" 31(2 3(.- $23 +`@3 /$ 04( "+H341$ +  1@ "3(.- (-%+ ,, 3.(1$ $3 ".11$2/.-# : 4-$ 1@/ 1 3(.- #$2 3(2242 $-#.,, &@2Z $/$-# -3W $++$ $23 2.45$-3 (-".,/+?3$$3/$43+ (22$14-$"(" 31("$Z  5$"+`@5.+43(.-#$2!(., 3@1( 47W 2xx  

(66)  

(67)       

(68)  

(69)  

(70) 

(71)       

(72)  

(73)  

(74)  

(75) 

(76) .    

(77) 

(78)     

(79) 

(80)    

(81)   

(82)

(83) 

(84) 1$%.1, 3(.-d#43(224Z  - / 1+$1  #.-" #$ 2?'?.?2!4)/.W +.1204$ +` 1"'(3$"341$ -.1, +$ $3 %.-"3(.--$++$ #$2 3(2242 2$1  1@3 !+($ !$ ).4%'25-xyZ + 2` &(3 #`4- /1."$2242 !$ 4".4/ /+42 ".,/+$7$ $3 #(%%("(+$ : .!3$-(1 $- 3'@1 /$43(04$xzZ $13 (-2 43$412$23(,$-3,A,$04$+ 1@&@-@1 3(.-".,/+?3$#$2+@2(.-2# -2+$23(2242/.23\- 3 47$23(,/.22(!+$2 -2 "(" 31("$x{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{" 3@&.1($2Y3/5342!#4)6%M!$$)4)6%M#/.$5#42)#% $3 ).$5#42)#%Z $ -.,!1$ #$ 1$"'$1"'$2 $- (-&@-($1($ 3(224+ (1$ 4&,$-3$ #$ , -(?1$ $7/.-$-3($++$$3 4-$ ./56%,,%$%.4)34%2)%$)4% U2?'?.?2!42)#%Vx| /.411 (3% (1$241% "$Z$2@34#$22$%." +(2$-3$-/ 13("4+($1241+$2 "$++4+$2$,!+@, 3(04$2#$+`@3$1-$++$)$4-$22$:2 5.(1+$2#%,,5,%33/5#(%3-?3%.#(9-!4%53%3x}Z +2` &(1 (3#.-" #$1@422(1: ++($1+$412" / "(3@2:"$++$2#$2!(., 3@1( 47W# -2+`.!)$"3(%#$1@&@-@1$1+$23(2242Z  .42/.45.-21@24,$1+ #$-3(23$1($,.#$1-$$3#$#$, (-2$+.-4-$"+ 22(%(" 3(.-(-@#(3$Y   > 1           >1         .       41$3 &$" 1($47W /4+/$"3.,($W 241% > &$W 54+2(.-. .      .     .   .  .     . 1.3'?2$2W (,/+ -3.+.&($.  1$%%$2W 1@&@-@1 3(.- &4(#@$.   "3$412#$ "1.(22 -"$WW  .  $++4+$22.4"'$2W (-&@-($1($3(224+ (1$. . .      Y `    . E.

(85)       . O   R U V   ,@#$"(-$ 1@&@-@1 31("$  /.41 .!)$"3(% #$ 1@&@-@1$1 4-$ +@2(.- .4 4- .1& -$ , + #$ 5.(1$ !2$-3 &1<"$ : +`43(+(2 3(.- #$ "$++4+$2 2.4"'$2Z .41 "$ % (1$W +$2 &1$%%.-2 43(+(2@2 #$51.-3 1@/.-#1$ : #$2 "1(3?1$2 !($- 2/@"(%(04$2Y .     N. . + $23 " /(3 + #$ /1./.2$1 4 / 3($-3 4-$ 3'@1 /$43(04$ /1@2$-3 -3 4-$")/#/-0!4)"),)4? /04)-!,% $- 3$1,$2 #$ 3.7("(3@$3#`(,,4-.&@-("(3@Z$4+4-42!.30,!.4!54/,/'5%#@%(-(3"$3(#@ +Z  $&1$%%.-(,/+ -3@#.(3@& +$,$-3A31$!(. "3(%W 431$,$-3#(3W(+#.(3A31$+` "3$41#$+ -@.%.1, 3(.-#$23(2242Z. +#.(3#.-"2$#(%%@1$-"($1#$2!(., 3@1( 47W04(/ 1#@%(-(3(.-2.-3#$2c, 3@1( 47-.-5(5 -3243(+(3@2# -24- #(2/.2(3(% ,@#(" + #$23(-@ : (-3$1 &(1 5$" +$2 2823?,$2 !(.+.&(04$2d h.-%@1$-"$ 41./@$--$ #$ .-2$-242 #$ '$23$1x€}ix~Z$33$-@.%.1, 3(.-#.(3.!@(1:+ 31( #$1$/1@2$-3@$/ 1Y \ Y //.13#$#%,,5,%36)6!.4%3" / !+$2#$1@&@-@1$1+$3(224"(!+$W \ R  Y +$ &1$%%.- #.(3 A31$ " / !+$ #$ /1.#4(1$ $3 #$ 1$"143$1 #$2 &!#4%523 $% #2/)33!.#% $3 #$ #(%%@1$-"( 3(.- %(-#`.1"'$231$1+ 1@&@-@1 3(.-W \  Y(+#.(3/.45.(1 &(1".,,$4-c?#(!&!5$!'%V/.41&4(#$1+ %.1, 3(.-3(224+ (1$W3.43 $-/$1,$33 -3+ ".+.-(2 3(.-#4&1$%%.-/ 1+$25 (22$ 47$3+$2"$++4+$2#4+(31$"$5$41Z.    N  \ \ \ \ \ \. ,(2$$-/+ "$#4&1$%%.-#$51 A31$!)3?%M2%02/$5#4)",%%4!$!04?%:3.43$2+$22(34 3(.-2"+(-(04$2 $&1$%%.-#.(3A31$#(2/.-(!+$$-15!.4)4?W$3&!#),%-%.4!##%33)",%M 3'@1 /$43(04$#$51 '?.?2%25.-).)-5-$%$/5,%52Y24(3$2./@1 3.(1$2,(-(,$2iW .-/1@+?5$,$-3W2 , -(/4+ 3(.-$32 1@(,/+ -3 3(.-#$51.-32%30%#4%2$%34%-03/0?2!4/)2%3 # /3@2 :-.31$$7$1"("$W $-!4?2)%, 1$04(2#$51 A31$-).)-!, $3% "(+$,$-3 ""$22(!+$/ 1+$2/1 3("($-2W 3'@1 /$43(04$#$51 A31$0%5/.?2%53%/.41+$/ 3($-3$3+$/1 3("($-Z.    N /$13$#$24!23 -"$2$31 #4(3/ 14-$#@%("($-"$,@" -(04$ 4-(5$ 4204$+$33(04$Z &1$%%$h.42.-24!23(343i #$51 .%%1(1 /1?2, 341 3(.-4-$2?3)34!.#%-?#!.)15%!$!04?%!53)4%%4;,!4!),,%$5$?&!54;2?0!2%2Z` 431$ / 13W +$ &1$%%.- #$51  ".-23(34$1 4-$ "!22)>2% 0(93)15% ".-31$ +$ #@5$+.//$,$-3 h/ 1 ".,/@3(3(.- "$++4+ (1$ : +`(-3@1($41#4#@% 43i#$3(22425.(2(-2#.-3+ 5(3$22$#$"(" 31(2 3(.-2$1 (3/+421 /(#$04$"$++$#43(224"(!+$xZ   ?1       . $% >.-(, &@$W+  1@&@-@1 3(.-3(224+ (1$ $23".,/ 1 !+$:+  ".-2314"3(.-#`4- !<3(,$-3# -2+$04$+ (-3$15($-3#(%%@1$-32 "3$412Y#$25@'("4+$2 04( //.13$-3+$2 , 3@1( 47-@"$22 (1$2 47.451($1204(5.-3+$2 22$,!+$1/ 1+$!( (2 #`4-@"' % 4# &$Z.  1               .      Y `    .  =<.

(86)        . O       Q @/ 22$1+$#., (-$/41$,$-31$".-2314"3(%#$+`.#.-3.+.&($1$23 41 31("$W$-#.#.-3(04$W/ 1.#.-3 +$W (,/+ -3 (1$/.41@5.+4$15$124-".-"$/3#$1@&@-@1 3(.-"+(-(04$,$-31@ +(2 !+$Z.    7 7 7 7. ".,/1$-#1$+$2/1(-"(/$2#$+`(-&@-($1($3(224+ (1$W #@".451(1+$/.3$-3($+#$"1.(22 -"$$3+ /+ 23("(3@#$2"$++4+$22.4"'$2#43(224 #(/$47W - +82$1+$2/1$,(?1$2 //+(" 3(.-2"+(-(04$2W #@& &$1#$2/$12/$"3(5$2#` //+(" 3(.-2 ""$22(!+$2$-.#.-3.23., 3.+.&($Z.   . .411$,/+(1"$2.!)$"3(%2W-.3 ,,$-3/.41/.45.(1 - +82$1+$/.3$-3($+#$#(%%@1$-"( 3(.-#$"$2"$++4+$2 2.4"'$2W +$ 31 5 (+ #$ 1$"'$1"'$ 2`$23 /.13@ 241 #$2 $22 (2 "+(-(04$2 1 -#.,(2@2Z  

(87)   

(88)    

(89)  

(90)     

(91) 

(92)   

(93)  

(94)   

(95)  

(96)        

(97)  #$2/ 3($-32h2(34 3(.-/$12.--$++$W'(23.1(04$,@#(" +ZZZiZ        

(98)  

(99)  

(100)     

(101)    

(102)   

(103)               

(104)

(105)                 

(106)

(107)      (-2($-" #1$1+ /1.%$22(.-Z.  R   $2 13("+$2 /.13 -3 241 +  , -(/4+ 3(.- #$ "$++4+$2 2.4"'$2 $,!18.-- (1$2 .4 #` 431$2 2.4"'$2 #$ "$++4+$2 ,@2$-"'8, 3$42$2h,.$++$.22$42$W+(& ,$-3/ 1.#.-3 +W/4+/ (1$[i 7 $2 13("+$2 /.13 -3 241 +  /$1%.1, -"$ #$2 #(%%@1$-32 38/$2 #`@"' % 4# &$2 28-3'@3(04$2 : 5(2@$ ".,,$1"( +$W 7 $2 13("+$2 /.13 -3 241 +  "'(141&($ $23'@3(04$W 04( 43(+(2$-3 +$ 3(224 #(/$47 ".,,$ , 3@1( 4 #$ ".,!+$,$-3h+(%3(-&W/+ 23($, ,, (1$W"'(141&($1$".-2314"31("$iW 7 $2 13("+$2/.13 -3241+ #(%%@1$-"( 3(.- #(/.&@-(04$#$2"$++4+$22.4"'$2#43(224 #(/$47W 7 $2 13("+$2/.13 -3241+`43(+(2 3(.-#$2"$++4+$22.4"'$2'.12#$+ 2/'?1$.1 +$h$7Y1$".-2314"3(.-2#$ %(2241$ - +$W.23@.\ 13'1.2$#$+ ' -"'$iZ.   . $2 1$"'$1"'$2 .-3 $4 +($4 241 { ,.(2 $3 .-3 @3@ $%%$"34@$2 241 +  ! 2$ #$ #.--@$2 4!$#W # -2 4- /1$,($1 3$,/2W2 -21$231("3(.-#$+ -&4$.4#$# 3$#$/4!+(" 3(.-Z   -2 4- /1$,($1 3$,/2 +$2 $  $1,2 Y c #(/.2$\#$1(5$# 23$, "$++ d .4 c 231., + 5 2"4+ 1 %1 "3(.- d .-3 @3@ 43(+(2@2Z x{ $22 (2 "+(-(04$2 1 -#.,(2@2 2.-3 1$22.13(2W /.13 -3 241 +$2 +(/.&1$%%$2W .23@. 13'1.2$ 13("4+ (1$W " 1#(./ 3'($2(2"'@,(04$2$3+$2%(234+$2 - +$2.-3@3@$7"+42Z  .41 /.45.(1 1@/.-#1$ 47 .!)$"3(%2 %(7@2W +  1$"'$1"'$  @3@ @+ 1&($ 47 %33!)3 #,).)15%3 #/.42B,?3W 47 2%65%3 3934?-!4)15%3 #$ +  +(33@1 341$ $3 : #$2 2!00/243 $% #!3       

(108)     

(109)       

(110) 

(111)    

(112)   

(113)      

(114)             2"($-3(%(04$2#$+`$22 ("+(-(04$"     

(115)  

(116)        #$/1$45$24%%(2 -3/.41@3 8$14-$3'?2$Z  $ $1,243(+2@2Y • c3(224$$-&(-$$1(-&d • c #(/.2$\#$1(5$# 23$,"$++2dW • c!4"" +% 3/ #d • c231., +5 2"4+ 1 %1 "3(.-d • c.23$.&$-("d. c!.-$1$&$-$1 3(.-d c!.-$&1 %3d c2(-42+(%3d c"'.-#1.&$-("d c3$,/.1., -#(!4+ 1 d • c/$1(.#.-3 +d. • • • • •. c&(-&(5 +d c,4".&(-&(5 +d c.#.-3.&$-("d c#$-3 + 1$&$-$1 3(.-d • c#$-3 +/4+/d • c.#.-3.!+ 23d • • • •. • • • • • • •. c.#.-3.+&8d c3$$3'd c2 +(5 18d c.1 +4+"$1d c#$-3 +d c(,/+ -3.+.&8d c".+$, -3$"'-("d. • • • •. cdWcd c2" %%.+#d c"$-31(%4& 3(.-d c -3$++($++d.   . +-`$7(23$/ 2$-".1$24%%(2 ,,$-3#$/1$45$22"($-3(%(04$2/.411$".,, -#$14-$ //1."'$3'@1 /$43(04$#$ +`43(+(2 3(.-#$2"$++4+$22.4"'$2#43(224 #(/$47/ 11 //.13:4- 431$/1."@#@#$1@&@-@1 3(.-3(224+ (1$Z (2 #`(,/.13 -3$2/(23$22.-3$-".412#` //1.%.-#(22$,$-3$3+$-.,!1$#`$22 (2"+(-(04$2".-31H+@2"'$9+` .,,$ "1.D3#$% >.-$7/.-$-3($++$Z.      Y `    .  ==.

(117)   .                          . O R      .      Y `    .  =>.

(118) `        . O        L & -. 7- '#(.((. *)--#& I)-,0, #(H0#.,)D (- &- )/.#&&-  0,, / &),.)#,D &- *,'#7,- 8.*-&# 8,(#.#)(&&/&-#(# 8,(#8--)/'#--/2#(/./,-0)/&/-G &-,#(.<.*)--#&I&&, *&/-&)#((-..0)#DI).(#,-&&/&-D*/#--),!(-"/.'(.-*8#&#-8-D/( )#D/(=/,D/(,.#&!D /()-M ( !&Wx€~zW1 -#$412$33$-3 3(.-2#$+ ,@#$"(-$x€Z . + % ++ (3 4-$ &1 -#$ 4# "$ (-3            

(119)            

(120) 

(121)     

(122) 

(123).  

(124)              

(125)                   

(126)  

(127)  

(128)     

(129)    #` 431$2 -$ 5.($-3 04`4-$ ,.1-$ +(&-$ #`'.1(9.-2 -21$+($%Z  -,@#$"(-$$3$-"'(141&($W#$-.,!1$42$2231 3@&($22.-3$,/+.8@$2:#$2%(-21@&@-@1 3(5$23$++$204$ +$2 43.&1$%%$2 $3 +$2 ++.&1$%%$2 (-2( 04$ +s43(+(2 3(.- #$ , 3@1( 47 28-3'@3(04$2Z $/$-# -3W +$412 +(,(3$2 .-3 /.422@ +$2 "'$1"'$412 : 2$ /.2$1 +  04$23(.- #$ +  3'@1 /$43(04$ (#@ +$ /.41 +$ 1$,/+ "$,$-3 #$2 /$13$2 3(224+ (1$2Zs$23 #$ +s(#@$ #$ +s43(+(2 3(.- #`4- 3(224 2 (- /.41 ".,!+$1 +  /$13$ 3(224+ (1$W 04s$23 -@ +$ ".-"$/3 #`(-&@-($1($3(224+ (1$.41@&@-@1 3(.-3(224+ (1$ywZ  - x€€zM    yxWyy #@%(-(22$-3 +s(-&@-($1($ 3(224+ (1$ ".,,$ c 4- "' ,/ #` //+(" 3(.- (-3$1#(2"(/+(- (1$ #$ +`(-&@-($1($ $3 #$2 2"($-"$2 #4 5(5 -3 5(2 -3 4 #@5$+.//$,$-3 #$ 24!23(3432 !(.+.&(04$2 /.45 -31$23 41$1W, (-3$-(1.4 ,@+(.1$1+ %.-"3(.-3(224+ (1$dZ  `(-&@-($1($3(224+ (1$".,,$-.45$ 4,.8$-3'@1 /$43(04$$23".-2314(3$241+$!(.,(,@3(2,$$31$/.2$241+  ".,/1@'$-2(.-#$+s(-3$1 "3(.-#$31.(2@+@,$-32yzY aO   M bO  M cO O  $/1(-"(/$#$+`(-&@-($1($3(224+ (1$$23#s 22."($14-")/-!4?2)!5")/#/-0!4)",%YZ$-2$,$-"@/ 1#$2      //1./1(@$2 ,4-($2 #$ -/,?#5,%3 ")/,/')15%-%.4 !#4)6%3 Y Z %(- #$ % 5.1(2$1 +  #(%%@1$-"( 3(.-$3+ , 341 3(.-"$++4+ (1$5$12+$3(224:1@&@-@1$1Z  s$23+ ".,!(- (2.-#$2#(%%@1$-32.43(+2#$+s(-&@-($1($3(224+ (1$04(/$1,$3#s(-#4(1$4-$1@&@-@1 3(.-3(224+ (1$ ./3(, +$y{Wy|Z  $33$31( #$#s@+@,$-32".-23(34 -3+s(-&@-($1($3(224+ (1$-s$23/ 22 -21 //$+$1+ ".,/.2(3(.-/1./1$#$ -.23(2242$3.1& -$204(2.-3$22$-3($++$,$-3".-23(34@2#$"$++4+$2 5$"+$41, 31("$$731 "$++4+ (1$h2" %%.+#i$3 #42823?,$#$2(&- +(2 3(.-(-3$1"$++4+ (1$Z   @1 4        .  . . 

(130) . .

(131) . .

(132) .  . .      Y `    .  =?.

(133) `         . O   ^        ' "4- #$2 ".,/.2 -32 #$ +s(-&@-($1($ 3(224+ (1$ "(3@2 "(\#$2242 1$/1@2$-3$ 4-$ //1."'$ #(%%@1$-3$W 1$2/$"3(5$,$-3Y +  31 -2/+ -3 3(.- "$++4+ (1$W +  ".-#4"3(.- $3 +s(-#4"3(.-Z ++$2 /$45$-3 A31$ $,/+.8@$2 (-#(5(#4$++$,$-3.4$- ".,!(- (2.-W %(-#s ,@+(.1$1+ 1@&@-@1 3(.-#4-@.\3(224%.-"3(.--$+y}Z.   .  ++$ % (3 //$+ : #$2 !(., 3@1( 47 43(+(2@2 #$ % >.- / 22(5$Z $41 1H+$ $23 #$ % "(+(3$1 +  "1.(22 -"$ .4 +  1@&@-@1 3(.-#s4-3(224#@):$7(23 -3Z   -2+s$7$,/+$#$+ 1@&@-@1 3(.-3(224+ (1$&4(#@$hiW"s$23+s43(+(2 3(.-#$+ ,$,!1 -$W %(-#$/1.3@&$1+$ " (++.3 2 -&4(-W 2.41"$ #$ "$++4+$2 (-3$15$- -3 # -2 +  "(" 31(2 3(.- / 1.#.-3 +$W 04( ".-23(34$ +$ ,@" -(2,$ #s.23@.".-#4"3(.-y~WyZ.      $33$ //1."'$ ".-2(23$ : 1$"143$1 $3 "3(5$1 #$2 "$++4+$2 ".,/@3$-3$2 : /1.7(,(3@ #4 #@%("(3 3(224+ (1$ / 1 +s43(+(2 3(.- #$ 2(&- 47 !(.+.&(04$2 2/@"(%(04$2Z s.1(&(-$ #$ "$ ,@" -(2,$ 5($-3 #$ +  #@".45$13$ #$2 .-$ .1/'.&$-(" 1.3$(-2 h2i $3 #$ +$41 $%%$3 c .23@.(-#4"3$41 d /$1,$33 -3 +  %.1, 3(.- #s.2 # -2 #$2 2(3$2 $"3./(04$2:/ 13(1#$/.4#1$#s.2#@,(-@1 +(2@$Zh x€}|y€WzwiZ.        $47"'.(72`.%%1$-3:-.42Y 7 %.a4%-03N+$2"$++4+$22.-3/1@+$5@$2$3#(1$"3$,$-331 -2/+ -3@$2# -2+$3(224"(!+$ 7 %. b 4%-03 N /1?2 5.(1 @3@ /1@+$5@$2W +$2 "$++4+$2 2.-3 ,4+3(/+(@$2 2$+.- +$2 /1(-"(/$2 #$ +  !(.+.&($ "$++4+ (1$W/4(2$-2$,$-"@$22414-24//.13 %(-#$+$21@(,/+ -3$1Z  s$23 +  ,4+3(/.3$-3( +(3@ #$2 "$++4+$2 2.4"'$2 43(+(2@$2 04( 1$-# /.22(!+$ $3 $%%(" "$ +  31 -2/+ -3 3(.- "$++4+ (1$Z$33$ //1."'$1$%+?3$!($-+$" 1 "3?1$,4+3(#(2"(/+(- (1$#$+s(-&@-($1($3(224+ (1$zxZ   A1   4      . .      Y `    .  =@.

(134) `        . O  ^       aO.         N.    N     . $2 "$++4+$2 2.4"'$2 .-3 #$47 /1./1(@3@2 /1(-"(/ +$2 Y ,R!54/2%./56%,,%-%.4 h$++$2 2$ ,4+3(/+($-3 $- #.-- -3 #$ -.45$++$2 "$++4+$2 2.4"'$2i $3 +  $)&&?2%.#)!4)/. h2.4,(2$2 : "$13 (-2 ,(+($47W $++$2 /1.#4(2$-3 #$2 "$++4+$22/@"( +(2@$2W/ 1$7$,/+$#$%.($W#$/ -"1@ 2W#$/$ 4W#$,42"+$W$3"ZiZ  /1?2+ %@".-# 3(.-#$+`.5."83$W(224#$+`.5 (1$W/ 14-2/$1, 3.9.E#$W+$2/1$,(?1$2"$++4+$2$,!18.-- (1$204( 2$#(5(2$-32.-33.43$2(#$-3(04$2$3#(3$2c4/4)0/4%.4%3dZ++$25.-3%.1,$1+`$,!18.-$3+$/+ "$-3 Z  $2"$++4+$2$,!18.-- (1$204(24(5$-3"$2/1$,(?1$2#(5(2(.-2"$++4+ (1$2-$2.-3/ 2$-".1$#(%%@1$-"(@$2X$++$2 2.-3c0,52)0/4%.4%3d" 1" / !+$2#$2$,4+3(/+($1$--`(,/.13$04$+3(224#$+`.1& -(2,$Z  $-`$2304` 4%41$3:,$241$#4#@5$+.//$,$-3#$+`$,!18.-04`$++$2#$5($--$-3#$/+42$- /+422/@"( +(2@$2 /.41%.1,$1+$2#(%%@1$-323(2242#$2.1& -$2Z  $2 "$++4+$2 c-5,4)0/4%.4%3V /$45$-3 %.1,$1 /+42($412 38/$2 #$ "$++4+$2 , (2 2$4+$,$-3 # -2 4- 38/$ #$ 3(224 #.--@h/ 1$7$,/+$+$2"$++4+$2#42 -&W"$++4+$2.22$42$2W@/(3'@+( +$2W #(/$42$2iZ  $2 "$++4+$2 2.4"'$2 c5.)0/4%.4%3V 2.-3 +(,(3@$2 : 4-$ +(&-@$ "$++4+ (1$ h/ 1 $7$,/+$ +$2 "$++4+$2 &$1,(- +$2W .5."83$2/.41+ %$,,$$32/$1, 3.9.E#$2/.41+$2'.,,$2iZ  `43(+(2 3(.-#$2"$++4+$22.4"'$2$,!18.-- (1$2$233.3 +$,$-3(-3$1#(3$$-1 -"$/ 1+$2+.(2#$(.@3'(04$zyW" 1 +$41 .!3$-3(.- -@"$22(3$ #$ #@314(1$ 4- $,!18.- .4 #$ 1@ +(2$1 4- "+.- &$ 3'@1 /$43(04$W "$ 04( 2.4+?5$ 4- #(+$,,$@3'(04$Z ).43.-2:"$+ 3.42+$21(204$2#$1$)$3$-1 (2.-#$+s(-".,/ 3(!(+(3@(,,4-.+.&(04$$-31$+$ #.--$41$3+$1$"$5$41Z `$23 $- 3$-3 -3 #$ ".-3.41-$1 "$2 +(,(3$2W 04`$- yww} 4-$ #$1-(?1$ /./4+ 3(.- #$ "$++4+$2 2.4"'$2  @3@ #@".45$13$W.4/+43H3c(-#4(3$dW/ 14-) /.- (2#$&,

(135) zzY+ #%,,5,%U)Vh/.41 (/&/,#*).(. .'&&iZ42$-2231("3W"$-`$23/ 24-$"$++4+$2.4"'$Y"`$234-$"$++4+$ #4+3$04(W,.#(%(@$&@-@3(04$,$-3241 04 31$#$2$2&?-$2W1$,$32.-'.1+.&$:9@1.Y$++$1$#$5($-3/1$204$4-$"$++4+$2.4"'$$,!18.-- (1$Z  +&1@ +$2 /1$,($12 $22 (2 (-%14"34$47W " 1 +`4- #$2 04 31$ &?-$2 /.45 (3 (-(3($1 4- /1."$2242 " -"@1$47W "$ "'$1"'$411$>4+$1(7.!$+#$@#$"(-$ywxy$3+` 43.1(2 3(.-#`$%%$"34$1#$2$22 (2'4, (-2Z+`'$41$ "34$++$W +`43(+(2 3(.-#$2"$++4+$2($23$-".1$(-3$1#(3$$-1 -"$/ 1+$2+.(2#$!(.@3'(04$2W, (2$++$21$/1@2$-3$-33.43 #$,A,$4-$ 5 -"@$, )$41$#$+ !(.3$"'-.+.&($Z $"'$,(-$23+.-&Z.            $2"$++4+$22.4"'$2#$51.-31@/.-#1$:#(%%@1$-32"1(3?1$2z{Wz|Y • A31$% "(+$2:2?#/,4%2Y2$+.-4- "3$2(,/+$W".#(%(@W1 /(#$W(-#.+.1$$32 -2,.1!(#(3@W • A31$% "(+$2:02?0!2%2Y(2.+$,$-31 /(#$W2 -2 #)45 -32@31 -&$12W • A31$% "(+$2:42!.30,!.4%2Y "3$, (31(2@W1$/1.#4"3(!+$W(-#.+.1$W • 5.(1 +$ /+42 + 1&$ @5$-3 (+ #$ #(%%@1$-"( 3(.- h0,!34)#)4?i -.3 ,,$-3 .23@.&@-(04$W / 1.#.-3 +$ $3 .#.-3.&@-(04$W • A31$a``j#/-0!4)",%3 5$"+$2(3$1$"$5$41/.41@5(3$1+$21(204$2#$1$)$3W • A31$-!@42)3!",%3Y@" 13$13.431(204$#$/1.+(%@1 3(.--.-".-31H+@$h38/$" -"@1(2 3(.-iW • A31$$-,$241$#$% (1$+ #(%%@1$-"$$-31$+$3(224"(!+$$3+s.1& -$Z  3$-!.-42W2("$2"$++4+$2/.22@# ($-3#$202/02)?4?3)--5./-/$5,!42)#%3h$%%$3c -3(1$)$3d- 341$+iW"$2$1 (3 +` /.3'@.2$] .      Y `    .  =A.

(136) `        .        P   %(- #` 2241$1 +  2@"41(3@ #4 / 3($-3W c/1(,4, -.- -."$1$dW +$2 "$++4+$2 2.4"'$2 //1./1(@$2 : +  #$-3(23$1($ 1@&@-@1 3(5$#$51.-3A31$2.4,(2$2:4-".-31H+$3.3 +#$/4(2+$41 #,(-(231 3(.-)4204`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s 431$2 3(2242 #4+3$2W 8 ".,/1(2 +$ #$1,$W +$ 3(224 #(/$47 $3 #(5$12 3(2242 #$-3 (1$2z}Wz~Z   -2 "$ 3 !+$ 4 2.-3 1$/$13.1(@$2 +$2 #(%%@1$-3$2 -("'$2W (-2( 04$ +$41 /.3$-3($+ #$ #(%%@1$-"( 3(.- (-\ 5(31.$3(-\5(5.z}Wz~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h(-3$23(- +$W'@/ 3(04$W/ -"1@ 3(04$i 23@.!+ 23$W #(/."83$2W    2".13(" + "'.-#1."83$2W,8."83$2   "(-(W #(/."83$W.23@.!+ 23$W + -#$2 +(5 (1$W" - 47     "'.-#1."83$ ".++$"3$412 2!)33%M/3M#!24),!'%M -53#,%M&/)%M#C52M$%.4 34?/",!34%M#?-%.4/",!34%M 15!3)).4?'2!,%Y,)'!-%.4     #(/.$2/#94%M(?0!4/#94%M-9/#94%M 0!2/$/.4!,M#?-%.4M /$/.4/",!34%M&)"2/",!34% $%.4).%M05,0%Z  5$" +$41 /.3$-3($+ / 1.#.-3 + $3 .23@.&@-(04$W +$2 "$++4+$2 2.4"'$2 #4 3(224 #(/$47 2.-3 #`$7"$++$-3$2 " -#(# 3$2:+ 1@&@-@1 3(.-(-31 \.1 +$zZ.    s43(+(2 3(.-#$+ 3'@1 /($"$++4+ (1$$-(-&@-($1($3(224+ (1$W/.41+ 1@&@-@1 3(.-#$2#@%("(32.22$47(-31 \!4"" 47 ".-2(23$1 (3#.-":/1@+$5$1#$2"$++4+$22.4"'$2,@2$-"'8, 3$42$2hi#$/4(2+ ,.$++$.22$42$W+$2&$1,$2 #$-3 (1$2W .4 ,($47 $-".1$ +  &1 (22$ /.41 +$2 $-2$,$-"$1 241 4- c@"' % 4# &$d $3 (-#4(1$ +$41 "1.(22 -"$ $3 #(%%@1$-"( 3(.-5$12+$3(224:1@&@-@1$1 5 -3#$+$21@(,/+ -3$1241+$2(3$#@%("(3 (1$z€Z.      Y `    .  =B.

(137) `        . bO M NU V.  4$++$04$2.(3+ 231 3@&($43(+(2@$W+s(-&@-($1($3(224+ (1$% (304 2(,$-33.4).412 //$+:#$2!(., 3@1( 47Z.   R     . $224//.132".11$2/.-#$-3:4-1@2$ 431(#(,$-2(.--$+1 //$+ -3+ , 31("$$731 "$++4+ (1$Z +2s &(3#.-"#$ 2314"341$2 /.1$42$2 1@2.1! !+$2 2$15 -3 #$ c ! 2$ d h, 31("$i : +  1@&@-@1 3(.- #$2 +@2(.-2 3(224+ (1$2Z +2 ".-23(34$-3 4- 1@2$15.(1 #s$ 4W #$ -431(,$-32W $3 #$ % "3$412 #$ "1.(22 -"$ /.41 +  /1.+(%@1 3(.- "$++4+ (1$Z .41 "$+ W+$22" %%.+#2#.(5$-32 3(2% (1$:#$2$7(&$-"$2/ 13("4+(?1$2{wW{xW{yW{zY . •. ! ")/#/-0!4)"),)4? N (+2 #.(5$-3 A31$ -.- " 1"(-.&?-$2W -.- (,,4-.&?-$2W $3 $-3(?1$,$-3 1@2.1! !+$2 / 1#$2/1."$2242!(.+.&(04$2# -2+$" 2#$!(., 3@1( 471@2.1! !+$2W. •. 5.(14-$3425#452% ).4%2.% h/.1.2(3@$33 (++$#$2/.1$2i".,/ 3(!+$ 5$"+s 33 "'$,$-3$3".+.-(2 3(.- #$2 "$++4+$2W +$41 /1.+(%@1 3(.- h".-#4"3(5(3@i X (-2( 04$ +  /1.#4"3(.- #s4-$ -.45$++$ , 31("$ $731 "$++4+ (1$/ 1"$2,A,$2"$++4+$2W. •.  " / "(3@ : ).4?'2%2 $%3 &!#4%523 ).$5#4%523 /.41 % 5.1(2$1 $3 #(1(&$1 +  "1.(22 -"$ #4 -@.\3(224 h.23@.(-#4"3(.-i2 -2/$1#1$2$204 +(3@2 1"'(3$"341 +$2W. • •. $24//.13#.(3/.45.(142!.30/24%2%4$?,)62%2"$2,.1/'.&?-$22 -2+$2#@- 341$1W s 1"'(3$"341$$3+ ".,/.2(3(.-#42" %%.+##.(5$-30%2-%442%,^!00/24$^5.%.?/P6!3#5,!2)3!4)/./.41+$ 31 -2/.13#$+s.78&?-$$3#$2!(.,.+@"4+$2W. •. 5.(1 4-$ &/2-% !$!04?% !5 $?&!54 $3 4-$ 2?3)34!.#% 35&&)3!.4% /.41 2.43$-(1 +$2 3(2242 # -2 +$ !43 #$ ,(,$1 4/+42/1?2+$2/1./1(@3@2/'82(04$2$3!(.+.&(04$2#43(2241$,/+ "@W. •. $1,$331$ +$ #/.42B,%M ,! 02?6)3)"),)4? %4 ,! 2%02/$5#4)"),)4? $5 4!58 $%$?'2!$!4)/.Z  5(3$22$ #$ 1@2.1/3(.-W+$224!23 -"$2+(!@1@$2+.12#$+ #@&1 # 3(.-#42" %%.+#W+$412(-%+4$-"$2241+$,(+($42.-3: /1$-#1$$-".-2(#@1 3(.-W. •. -%(-W +$ !(., 3@1( 4 #.(3 A31$ % !1(04@ 5$" #$2 -!4?2)!58 !'2??3 / 1 +$2 .1& -(2,$2 - 3(.- 47 $3 (-3$1- 3(.- 47#$-.1, +(2 3(.-Z.   &1 -#$ #(%%("4+3@ #$ ".-"$/3(.- #$ "$2 24//.132 1@2(#$ # -2 +  3$-3 3(5$ #s(-3@&1 3(.- #$ +s$-2$,!+$ #$ "$2 $7(&$-"$2Z  1 $7$,/+$W +s //.13 #$ "$++4+$2 $3 #$ !(.,.+@"4+$2 $23 , 7(,(2@ $- 4&,$-3 -3 +  /.1.2(3@Z  1 ".-31$"$33$ 4&,$-3 3(.-#4-.,!1$#$/.1$2/$43#(,(-4$1+$2/1./1(@3@2,@" -(04$2#$+s@"' % 4# &$Z .    .   .  .,!+$,$-3.22$47W/$13$#$3(2242,.42W 33$(-3$/4+/ (1$W%(!1.2$#`4-$&+ -#$2 +(5 (1$Y$-%.-"3(.-#$+ 3 (++$ $3#438/$#$#@% 43W-.42 5.-2!$2.(-#`@"' % 4# &$2#(%%@1$-32Z  .("(04$+04$2& +@-(04$2Y   C1    .   .   .  N. "(#$'8 +41.-(04$ .+43(.- +(-$hi.  . . . . .++ &?-$  -&$-. (.\22  13("4+$2.1 (+.  . . 2 ++.&@-(04$ \.      Y `    . .  =C.

(138) `        . .("(1@24,@2+$2#(%%@1$-3238/$2#$24//.13243(+(2@2:"$).41{{W{|Y   .  .   .   N   . 354/'?.)15%. 43.&@-(04$. 3,,/'?.)15%. 4, (-$ h3A3$2%@,41i. 3?./'?.)15%. .5(-.         W  . 9$2/890!4)4%  ]P(/30(!4% 2)!,#)15%N]P  )0(!3?%N P. (-@1 +$. )/6%22%3. (-@1 +$. /2!),N #!2"/.!4%$% #!,#)5- /,,!'>.%3 #)$% (9!,52/.)15%.    . /,,%3W%,$% &)"2).%N ()4/3!.. ,').!4%'!2/3% ,<42%N0,<42%$% !2)3 )-%.43 /,9-?4(9-?4! #29,!4%3.     .    N  . . •. #)$%3 0/,9,!#4)15%   #)$% 0/,9',9#/,)15%  /,9?4(9,>.%P ',9#/,. (-@1 +$. (-@1 +$.  • • • • •. 43.&@-(04$ 23@.(-#4"3$41 23@.".-#4"3$41 23@.(-#4"3$41 23@.".-#4"3$41. • 23@.".-#4"3$412 (.".,/ 3(!(+(3@ (. "3(% (.,(,@3(04$ 23@.".-#4"3$412 .,/.2(3(.-"'(,(04$ /1."'$#$+ /' 2$ ,(-@1 +$#$+`.2 • 1./3$-2(. "3(5$2 • 1?2!(. "3(%2Y "'(,(.3 "3(2,$‚‚ • • • • •. • (.".,/ 3(!+$ • .1.2(3@2(,(+ (1$:+`.2 7.204$+$33$2 2/.-&($47 ,(-@1 47 • @2.1! !+$ • .--$1@2(23 -"$:+  ".,/1$22(.- $1,$!.5(- • (.".,/ 3(!(+(3@ • (. "3(% 1A3$2#$".0 • (.#@&1 # !+$2 .4-.- -(, +$ • .22(!(+(3@#` %%(-(3@ - 341$++$/.41+$2 43.&@-(04$ % "3$412#$"1.(22 -"$ • .--$ #'@2(.-"$++4+ (1$ • ,/1$22(.-z -(, +$ • (.".,/ 3(!+$ • (.#@&1 # !+$ •  / "(3@#$"'@+ 3(.- • 8#1./'(+$ @&@3 +$ • "3(5(3@'@,.23 3(04$ •  "3@1(.23 3(04$ • .--$1@2.1! !(+(3@hx\y (-@1 +$ ,.(2i. 8-3'@3(04$. $1,$-3 3(.- 28-3'@3(04$ 8-3'@3(04$ 8-3'@3(04$. /,,!'>.%P /,,!'>.%P (9$2/89!0!4)4%. (73$. P#%,,5,/3%. (73$. (73$. • • • • • • • • • •.   .1!(#(3@2(3$/1@+$5$41. .  . . . ‚‚‚ ‚. 23@./41$. ‚‚‚. (.\22. ‚‚. $1 / 3(3$. ‚‚. -&$-(2 h(,,$1i. ‚‚.  28&1 %3 $1 %.1,. • @24+3 322.45$-3 (-".-23 -32. ‚‚. $1(.&+ 22. • 1 &(+$# -2#$2 &1 -#$21$23 41 3(.- • (-@3(04$#$1@2.1/3(.- 5 1( !+$$-%.-"3(.-#4 2(3$. ‚. (.".1 +. ‚.  -&$-. ‚‚‚. 45$#$1,. . . ‚‚.

(139) .8.'$,. ‚. +&./.1$. ‚. (%$".1$. ‚. (./+ -3W . ‚. (&, . ‚. (&, . ‚. (&, . • .L3 • (204$#$ ".-3 ,(- 3(.- / 3'.&?-$ • .-, ++@ !+$2 •  1%.(2-.-1@2.1! !+$2 •  (!+$1@2(23 -"$ ,@" -(04$h.2 2/.-&($47i. • (204$#$ ".-3 ,(- 3(.- / 3'.&?-$ • .-.23@.".-#4"3$412 • .-.23@.".-#4"3$41. •  (!+$1@2(23 -"$ • @&1 # 3(.-+$-3$ • (22.+43(.-(,/1@5(2(!+$ (-5(5.. • .-.23@.".-#4"3$41. 23@.".-#4"3$412 23@./'(+$ • .-1@2.1! !+$.431?2 8#1./'(+$ +$-3$,$-3 .-24//.13#$,.+@"4+$2 ".,,$ • 8#1./'.!$2 8-3'?2$21$/1.#4"3(!+$2 • @ "3(.-2 .-(,,4-.&?-$2 (-%+ ,, 3.(1$#4$: (.".,/ 3(!+$2 "$13 (-2/1.#4(32#$  ++@ !+$2 #@&1 # 3(.- 3@1(+(2 3(.-% "(+$ • .+5 -3.4 &$-3#$ .#(%( !+$"'(,(04$,$-3 1@3("4+ 3(.-/.45 -3 h%.-"3(.-- +(2 3(.-i #@- 341$1+$2/1.3@(-$2. • 5 -3 &$#$"' "4-#$2 ".-23(34 -32 • (.".,/ 3(!+$2 • .--$2/1./1(@3@2 !(.,@" -(04$2. [. • 8-3'?2$/+42".,/+$7$ • (204$#$ ".-3 ,(- 3(.-% (!+$ , (2-.--4+. ‚‚. ‚‚ ‚‚. (.22.++ &$-W (.23(3$W $/&$-. .43 //1.7(, 3(%uY‚hx\|wiW‚‚h|w\xwwiW‚‚‚hxww\ywwiW‚‚‚‚hzww\|wwi.      Y `    .  =D.

(140) `        . cO  M   N 1.(2(?,$ "3$41#$+`(-&@-($1($3(224+ (1$Y+$2% "3$412#$"1.(22 -"$$3#$#(%%@1$-"( 3(.-"$++4+ (1$2.-3 @3@43(+(2@2/.41% 5.1(2$1+s(-3@&1 3(.-3(224+ (1$#$2, 3@1( 47(,/+ -3@2Z  $411H+$$23#$/$1,$331$+$1$"143$,$-3W+ /1.+(%@1 3(.-$3+ #(%%@1$-"( 3(.-#$2"$++4+$22.4"'$2$-5(1.-- -3$2Z -$ #$2 /1(-"(/ +$2 +(,(3$2 #$ +s43(+(2 3(.- #$ "$2 % "3$412 #$ "1.(22 -"$ $23 04s(+2 /.411 ($-3 $-31 D-$1 4-$ /1.+(%@1 3(.- "$++4+ (1$ -.- ".-31H+@$ 2( +$41 #(%%42(.- -s@3 (3 / 2 +(,(3@${}Z .41 @5(3$1 "$3 (-".-5@-($-3W #$2 2823?,$2#$".4/+ &$$3#$+(!@1 3(.-".-31H+@$.-3 (-2(@3@,(2 4/.(-3{~Z   1,(+$2% "3$412#$"1.(22 -"$W-.42"(3$1.-2Y.       1@C.      1A;0A<.     1@<6@D.     391?C6@;. .  4  • 4(22 -3/1.,.3$41#$ • .45.(1,(3.&?-$,.#$23$ • 3(,4+$Y o +$".++ &?-$38/$xW o + !(.28-3'?2$#$%(!1.-$"3(-$$3#s.23@.-$"3(-$ o + #@/.2$#$, 31("$.22$42$ • .45.(1#$"'(,(.3 "3(2,$ • (,(-4$+ #$2314"3(.-#$+ , 31("$#43(224".-).-"3(%$-1@&4+ -3:+ ! (22$+  28-3'?2$#s "3(5 3$41#$,@3 ++./1.3@(- 2$$3#$/+ 2,(-.&?-$ • -'(!$+ %.1, 3(.-#s.23@."+ 23$2, (2% 5.1(2$+ 1@2.1/3(.-.22$42$/ 14- ,@" -(2,$(-#4(3/ 1+ /1.23 &+ -#(-$ • (3.&@-(04$ #$Y o W/1@"42$412.23@.!+ 23(04$2W/1@"412$412"'.-#1."83 (1$2 • -#4(3+`$7/1$22(.-#4/'@-.38/$Y o .23@.!+ 23(04$$- 4&,$-3 -3+` "3(5(3@#$+ /'.2/' 3 2$ +" +(-$h i # -2+$2"$++4+$2.22$42$2 o "'.-#1."83 (1$# -2+$" #1$#s4-$.22(%(" 3(.-$-#."'.-#1 +$ • @&4+$Y o +` 33 "'$"$++4+ (1$ -"1 &$\#@/$-# -3h%(!1.-$"3(-$i o + #(%%@1$-"( 3(.-.23@.!+ 23(04$ o +` "3(5(3@ W+ 28-3'?2$.23@." +"(-$e,(-@1 +(2 3(.- o +s /./3.2$"$++4+ (1$ • $1 (31$2/.-2 !+$#$+`(-(3( 3(.-#$+ "@,$-3.&@-?2$$3#$+ 1@&4+ 3(.-#$ +` 22$,!+ &$%.-"3(.--$+#4+(& ,$-3 +5@.+.#$-3 (1$ • H+$# -2+ ,.1/'.&@-?2$#$-3 (1$Y o \yW\~W\{2.-3$7/1(,@2# -2+`@/(3'@+(4,#$-3 (1$ o \zW\~2.-3$7/1(,@2# -2+$#@5$+.//$,$-3+(& ,$-3 (1$ o \y$23$7/1(,@+.12#$+ ,.1/'.&@-?2$#$+ 1 "(-$ o \z 41 (34-1H+$# -2+ +(&-@$"@,$-3.!+ 23(04$ • yY4(22 -3,(3.&?-$#$2 •  -2+$2/' 2$2/1@"."$2#$+ "(" 31(2 3(.-Y o (+% 5.1(2$+ /1.+(%@1 3(.-W+ ,(&1 3(.-W+ #(%%@1$-"( 3(.-#4+(& ,$-3 o (+#(,(-4$+ #(%%@1$-"( 3(.-"@,$-3.!+ 23(04$$3.23@.!+ 23(04$+(,(3 -3+  %.1, 3(.-#$3(224#41 •  -2+$2/' 2$23 1#(5$2#$+ "(" 31(2 3(.-Y o (+".-31(!4$:+ %.1, 3(.-#$+ , 31("$$731 "$++4+ (1$$3+` -&(.&@-?2$W % "(+(3 -3+ %.1, 3(.-#$+(& ,$-3/ 1.#.-3 + o H+$# -2+ ,.1/'.&@-?2$$,!18.-- (1$ • .,.#(,?1$ 4&1 -#/.45.(1 o (3.&?-$ o #$"'(,(.3 "3(2,$$-5$12+$2"$++4+$2+(& ,$-3 (1$2 o #$!(.28-3'?2$#$+ , 31("$$731 \"$++4+ (1$ o /1.,.3$41#$+` -&(.&@-?2$ • 3(,4+$Y o + %.1, 3(.-#$3(224".-).-"3(%Y(+ &(3:4-23 #$/1@"."$#$+ 1@/ 1 3(.-W $-1$,/+(22 -3$3$-23 !(+(2 -3+ /+ ($Z o 28-3'?2$#$2%(!1.!+ 23$2&(-&(5 47Y4-/1@1$04(2/.41+ %.1, 3(.-#$ + 1&$2 &1@& 32#$/1.3@.&+8" -$204(%.41-(22$-3+ 31 ,$-@"$22 (1$/.41 + Z.  . . . . .      Y `    .  =E.

(141) `       .      AC6B;.       5        AA0AB.       A?0A@.   3

(142)    1A=0A>. . • xY o 8-3'@3(2@/ 1+$2.23@.!+ 23$2W(+).4$1 (34-1H+$ 43."1(-$# -2+  %.1, 3(.-.22$42$ o (+23(,4+$Y  + ,(3.&@-?2$  + !(.28-3'?2$#$2, 31("$2#$" 13(+ &$W#s.2W#$3$-#.-$3#$ "$++4+$2,42"4+ (1$2  + /1.+(%@1 3(.-#$2"$++4+$2.23@."+ 23(04$2,4+3(-4"+@@$2 • \yY o $/+42 !.-# -3% "3$41#$"1.(22 -"$# -2+ , 31("$.22$42$ o 1.#4(3/ 1+$2.23@.!+ 23$2W(+23(,4+$+ %.1, 3(.-.22$42$$-(-#4(2 -3Y  + /1.+(%@1 3(.-$3+ #(%%@1$-"( 3(.-#$2"$++4+$2.22$42$2  + !(.28-3'?2$#$".++ &?-$38/$x • $,!+$ 5.(131?2/$4#`$%%$32241Y+ /1.+(%@1 3(.-#$2"$++4+$2+(& ,$-3 (1$2W+$41 ,(3.&@-?2$W+$"'(,(.3 "3(2,$W+ 28-3'?2$#$+ , 31("$+(& ,$-3 (1$ • $/$-# -3W(+).4$1 (34-1H+$#$23 !(+(2 3$41#4/'@-.38/$%(!1.!+ 23(04$W2  #(,(-43(.-$-31 (-$+ #(%%@1$-"( 3(.-#$2"$++4+$2$-.23@.!+ 23$2.4 "@,$-3.!+ 23$2Z • .41"$#$,.+@"4+$22(&- + -3$2 • .-3($-3Y o 4-$5 1(@3@#$% "3$412#$"1.(22 -"$YWW WWW o #$2%(!1(-.&?-$204(2.-32"(-#@2$-%(!1(-$/.41 ""@+$1$1+ "(" 31(2 3(.- #$+ /+ ($ • 4&,$-3$+$1$"143$,$-3W+ /1.+(%@1 3(.-$3+ #(%%@1$-"( 3(.-#$2"$++4+$2 (,/+(04@$2# -2+ 1@&@-@1 3(.-3(224+ (1$ • 731 (3#$+ , 31("$#s@, (+/.1"(-$ • ++$$23".,/.2@$Y o #s ,@+.&$-(-$W/1.3@(-$#$+ , 31("$#$+  W04().4$4-1H+$# -2+  "@,$-3.&@-?2$ o #s 431$2/1.3@(-$2#$+ , 31("$W#$% "3$412#$"1.(22 -"$3$+204$\yW\{ W\m (-2(04$#$,.+@"4+$23.4).412(-".--4$2Z • @&4+$Y+ /1.+(%@1 3(.-W+ ,(&1 3(.-W+s #'@2(.-W+`$7/1$22(.-&@-(04$$3+  /1.#4"3(.-#$"83.*(-$2W#$/1@\.23@.!+ 23$2W#$%(!1.!+ 23$2/ 1.#.-3 47$3#$ %(!1.!+ 23$2&(-&(5 47 • $2@34#$2(-5(31.1@"$-3$2.-33$-3@#$1$"$-"$1+$2 "3(5(3@2!(.+.&(04$2#$ $22$-3($++$2:+ 1@&@-@1 3(.-/ 1.#.-3 +$:2 5.(1Y o + 23(,4+ 3(.-#4"'(,(.3 "3(2,$W#$+ /1.+(%@1 3(.-$3#$+ #(%%@1$-"( 3(.- #$2"@,$-3.!+ 23$2W#$2.23@.!+ 23$2$3#$2"$++4+$2+(& ,$-3 (1$2 o +s(-#4"3(.-#$+s -&(.&@-?2$Z. . . . . .  ^.    s$%%$3#$3.42"$2% "3$412#$"1.(22 -"$241+ %.1, 3(.-$3+ 1@/ 1 3(.-.22$42$#@/$-##$/+42($412 "1(3?1$2Y,%#(/)8$%,!02/4?).%M,!$/3%!00,)15?%M%4,%-/$%$R!00,)#!4)/.O . $2 % "3$412 #$ "1.(22 -"$ @3 -3 1 /(#$,$-3 @+(,(-@2 / 1 +s.1& -(2,$W (+2 -@"$22(3$-3 +  ,(2$ $- J451$ #s4- 2823?,$#$+(!@1 3(.-04(/$1,$331 (3#$/.3$-3( +(2$1+$41 "3(5(3@!(.+.&(04$#$% >.-+." +$W".-31H+@$$3#41 !+$ 4 -(5$ 4 #4 2(3$ #$ 1@/ 1 3(.-Z $ 2823?,$ #$ +(!@1 3(.- #.(3 @& +$,$-3 /$1,$331$ #$ +(,(3$1 +  04 -3(3@ #$ /1.3@(-$ (,/+ -3@$W 1@#4(2 -3 (-2( 2  #(%%42(.- 2823@,(04$ $3 +$2 1(204$2 #s$%%$32 (-#@2(1 !+$2Z - #(23(-&4$ y ,.#$2#` //+(" 3(.-~xW~yY 7 ,R).*%#4)/.).P3)45#$% "3$412#$"1.(22 -"$241+$2(3$ 7 ,! 4(?2!0)% '?.)15%Y $++$ ".-2(23$ : (-2@1$1 4- &?-$ # -2 +$2 "$++4+$2 2.4"'$2 /.41 4&,$-3$1 +$41 $%%(" "(3@% "$:4-$-5(1.--$,$-3'.23(+$$3/.412@"1@3$14--.,!1$(,/.13 -3#$% "3$41231./'(04$2Z o -\5(5.+.1204$+$&?-$$23#@+(51@#(1$"3$,$-3241+$2(3$W o 7\5(5.W+.1204$+$2"$++4+$22.-3,.#(%(@$2&@-@3(04$,$-3+.12#`4-$@3 /$+ !.1 3.(1$Z. dO   N   ".,!(- (2.- #$ +s$-2$,!+$ #$ "$2 3$"'-(04$2 /.411 (3 1@/.-#1$ 4 #@2(1 #$ "1@$1 #$2 2.+43(.-2 /+42 !(.+.&(04$2:+s(,/+ -3 3(.-/$1, -$-3$#$!(., 3@1( 47(-$13$2Z $23$"'-(04$2/$1,$33$-3W/ 1+ ".,/1@'$-2(.-$3+$".-31H+$#$2(-3$1 "3(.-2$-31$+$2,.+@"4+$2#$+ , 31("$ $731 "$++4+ (1$$3#$2"$++4+$22.4"'$2".,/@3$-3$2W,.#(%(@$2&@-@3(04$,$-3.4-.-/.41% 5.1(2$1+s$7/1$22(.- #$"$13 (-2&?-$23$+204$+$22W$3 ,$-@$2241+$2(3$5( 4-24//.13 # /3@W#s !.43(1:+ #(%%@1$-"( 3(.-$3 + "1.(22 -"$#4-@.\3(224#@2(1@# -2+$!43#$1@&@-@1$14-$+@2(.-.22$42$Z.      Y `    .  ><.

(143)   .                           . O   M     .      Y `    .  >=.

(144)   W     . .-&3$,/2 ".-2(#@1@ ".,,$ 4- 2(,/+$ 3(224 #$ 23."* &$W /4(2 (,/+(04@ # -2 +$2 #821@&4+ 3(.-2 $-#."1(-($--$2$3,@3 !.+(04$2W+$3(224 #(/$47& &-$ "34$++$,$-34-$(, &$!$ 4".4//+42/.2(3(5$".,,$ 1@2$15.(1 !.-# -3 #$ "$++4+$2 /.41 +  3'@1 /($ 1@&@-@1 31("$Z 1@2$-3.-2 "$3(224 c31@2.1d #$ +`(-&@-($1($ 3(224+ (1$Z . O    

(145)       '$9 +$2 , ,,(%?1$2W -.42 1$31.45.-2 #$47 38/$2 #$ 3(224 #(/$47 #(23(-"32 #.-3 +$2 1H+$2 ,@3 !.+(04$2 2.-3 #(23(-"32$3".,/+@,$-3 (1$2~zZ.      $4738/$2/.41#$47%.-"3(.-2Y 7 )335!$)0%583/53P#54!.?N1@/ 13($-y".4"'$224/$1%("($++$$3/1.%.-#$ o H+$#$23."* &$e2314"341$ 7 )335!$)0%586)3#?2!,N(-31 /@1(3.-@ +h.,$-3 +W,@2$-3@1(04$W/@1(&.- # +i$31@31./@1(3.-@ + o H+$$-#."1(-($-  $ 3(224 #(/$47 !+ -" 2241$ /+42($412 %.-"3(.-2Z .43 #` !.1#W +        

(146) Y 

Références

Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to