Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

To address this problem, in this study, we tested the immunomodulatory activity of the novel sensitive mAbs against bovine PD-L1 and LAG-3 established in recent studies [ 20 , 21

In both models, the depletion of macrophages provoked a strong increase in the percentage of CD8 T cells, but not of natural killer (NK) or other myeloid cells, at the tumor site; CD4

The expression of PD-1 and its ligands, PD-L1 and PD-L2, was assessed by flow cytometry on peripheral blood mononuclear cells (PBMC) and compared to patients who had

Again, CXCR5 + cells were largely confined to the DPOS population with signifi- cantly higher frequencies in comparison to the DNEG and PD-1 populations regardless of the time

We found that the intercellular transfer of NY-ESO-1 induced by MV sensitizes presenting tumor cells to the cytotoxic activity of the NY67 T cell clone in both models: the

In accordance with this, vibrational spectroscopy shows that a fully interconnected structure comprising tetrahedral units corresponds well to the IR/Raman signatures for glasses

Multimodal Mn-doped I-III-VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application.... This paper is originally

Tumor mutational burden and response to PD-1 inhibitors in a case series of patients with metastatic desmoplastic melanoma.4. Tumor mutational burden and response to programmed