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Role of the Protein Tyrosine Kinase 7 gene in human neural tube defects

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Academic year: 2021

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Fig. 1. Representative NTDs and their defective sites in neural tube closure. A: Normal neural tube formation marked with 5 closure initiating sites
Fig. 2. Transverse sections for neural tube formation. Neural plate is induced by notochord under it (A)
Fig. 3. Schematic diagram of cytoskeleton rearrangements in neural tube formation. In cuboidal neuroepithelial cells prior to neurulation (A), F-actin exists in a thin circular band (red) at apical junction, while microtubules (green) are diffusively dis
Fig. 4. Schematic diagram of secondary neurulation. The bilateral mesenchymal cells under the epithelial ectoderm (A) proliferate, migrate and finally condensate at the midline (B, C)
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