• Aucun résultat trouvé

Sleep loss changes executive brain responses in the wake maintenance zone

N/A
N/A
Protected

Academic year: 2021

Partager "Sleep loss changes executive brain responses in the wake maintenance zone"

Copied!
1
0
0

Texte intégral

(1)

Sleep loss changes executive brain responses in the wake maintenance zone

Mathieu Jaspar1, 2 *, Christelle Meyer1, 2 *, Vincenzo Muto1, 2 *, Anahita Shaffii-LeBourdiec1, 2, Sarah Chellappa1, 2, Caroline Kussé1, Gilles Vandewalle1, 2, Fabienne Collette1, 2,Benita Middleton3, Simon

Archer3, Derk-Jan Dijk3, Pierre Maquet1, 2 1

Cyclotron Research Centre, University of Liège, Belgium 2

Welbio, Belgium 3

Surrey Sleep Research Centre, University of Surrey, Guildford, UK

* These authors equally contributed to the present work.

Objectives: Brain mechanisms underlying executive processes are regulated by circadian and sleep homeostatic processes. Furthermore, during sleep deprivation (SD), cognitive performance and neural responses are differentially modulated by a clock gene PERIOD3 polymorphism. Here, we investigated inter-individual differences on executive brain responses under SD. Critically, we focused on the circadian evening wake maintenance zone (WMZ), a key time-point for sleep-wake regulation. Methods: Thirty healthy young volunteers, genotyped for the PER3 polymorphism (10 PER35/5;20

PER34/4 homozygotes), underwent42-h SD under constant routine conditions. They performed a 3-back working memory task in 13successivefMRI sessions. To compare neural activity in the WMZ before and during SD, sessions were realigned according to individual dim light melatonin onset. Results: We tested for a group (PER35/5>PER34/4) by session effect (WMZ before vs. during SD). From the first evening WMZ(i.e. during a normal waking day) to the second (i.e. following 40h of continuous waking), PER35/5individuals relative toPER34/4showed significantly larger increase in responses in the left mid-cingulate, bilateral precuneus and thalamus. Interestingly, these regions are involved in executive processes and arousal regulation (thalamus).

Conclusions: These results show that the strong circadian wake-maintenance signal depends on sleep pressure, in a PER3-genotype dependent manner. Interestingly, pronounced genotype differences were observed in the thalamus, an area that compensates potential lower cortical activity under SD.

Références

Documents relatifs

Nous sommes les chainons de cette unique ronde Nos esprits évoluent dans l’esprit qui nous fonde Vivre dans l’hypothèse qui nous oblige à naitre S’accrocher au sujet qui

As a proof of principle that the synthesis of heterotelechelic polymers in one pot can be achieved following this route, exo-N-methyl norbornene imide (MNI, 17 equiv, 3 h) was added

Without the trade that a robust money supply evokes, “the Common People in general will be impoverished, and consequently obliged to sell More Land for less Money than they will do

Dans une étude publiée dans Cell Meta- bolism [13] , nous avons mis en évidence qu’un déséquilibre entre l’élastase, une enzyme pro-inflammatoire sécrétée par

[20] ——, “Informed Source Separation Using Iterative Reconstruction,” IEEE Transactions on Audio, Speech, and Language Processing, vol.. Vincent, “Consistent Wiener Filtering

The theory fur- ther predicts generation of long-scale structures and various correlations between the density, temperature and the (mag- neto) acoustic as well as convective

They also define another process by pruning at branches the tree conditioned on non-extinction and they show that, in the special case of Poisson offspring distribution,

Some algorithms for synchronizing clocks of base transceiver stations in a cellular network Jean Louis Dornstetter, Daniel Krob, Michel Morvan, Laurent Viennot.. To cite this