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A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer

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Academic year: 2021

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Fig. 1.   Population pharmacokinetic model for indisulam. The model comprises three compartments (central,  periph.1, and periph.2) with saturable distribution to one of the peripheral compartments and a linear and  saturable pathway of elimination from th
Table 2. Grade 3 and 4 toxicities
Fig. 2. Progression-free survival. Kaplan Meier plot of progression-free survival following indisulam given as a  daily × 1 schedule (—) or as a daily × 5 schedule (----------)
Table 3. Summary of estimated pharmacokinetic variables  PK variable  Variable estimate  Interindividual
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