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Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

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Academic year: 2021

Partager "Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy"

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Fig. 1 RANK expression in dystrophic skeletal muscles. a A quantitative real-time PCR analysis revealed that muscle RANK expression is increased by 5.5-fold in dystrophic EDL muscles relative to control
Figure S2). Muscle-specific RANK deletion significantly increased the specific and absolute forces of dystrophic EDL muscles by 87% and 54%, respectively, when
Fig. 3 Full-length OPG-Fc, but not muscle RANK deletion, prevents eccentric contraction-induced muscle dysfunction
Fig. 5 Schematic representation of the signaling pathways through which full-length OPG-Fc may exert its effects on skeletal muscle.
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