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Adult hippocampus neurogenesis in healthy and Alzheimer subjects

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Academic year: 2021

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ADULT HIPPOCAMPUS

NEUROGENESIS IN HEALTHY AND

ALZHEIMER SUBJECTS

MEYER FRANÇOIS (MD, PhD student)

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

ADULT HIPPOCAMPUS NEUROGENESIS (AHN)

▸ Addition of new neurons throughout life into the dentate

gyrus (DG)

At the core of hippocampus plasticity ▸ Well described in rodents

▸ First described in humans in 1994 (Eriksson et al.) but lack

of consensus

▸ Limited availability of human tissue and heterogeneity of

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

POPULATION

13 healthy Braak 0 subjects (age 43 - 87y)

45 AD subjects (age 52 - 97y) distributed among Braak I -

Braak VI

Brains obtained under controlled conditions and

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EC CA1 DG CA3

DCX : doublecortin (immature neurons)

NeuN : Neuronal nuclei (mature neurons)

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

MODEL OF DIFFERENTATION STAGE IN HUMAN ANH

▸ Well-characterized sequence of maturation stages in rodents ▸ PROX 1 = Protein/Gene produced primarily in dentate gyrus ▸ Co-expression DCX+ / POX 1 (91%)

▸ Subpopulations of DCX+ cell with variable degree of maturation in

human dentate gyrus

CR : Calretinin CB : Calbindin

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

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DATABLITZ NEUROSCIENCES CLINIQUES 14/12/19

TAKE - HOME MESSAGE

Detection of AHN markers in humans is critically

dependent on fixation conditions and pretreatment of the tissue

Demonstration of AHN in the adult human dentate gyrus

until the ninth decade of life

First model of differentiation stage of human ANH

Impairment of the maturation with Alzheimer’s disease,

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