Cytométrie en flux des microparticules : application à la thrombopénie induite par l'héparine

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MÉMOIRE

DU DIPLÔME D’ÉTUDES SPECIALISÉES

DE BIOLOGIE MÉDICALE

! ! Soutenu le 09 octobre 2017 ! ! !

Par Mme FRITZ Shirley Né(e) le 09 mai 1989 !

Conformément aux dispositions du décret n°2003-76 du 23 janvier 2003, tenant lieu de !

! !

THÈSE

!

POUR LE DIPLÔME D’ÉTAT DE DOCTEUR EN

PHARMACIE

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TITRE :

!"#$%&#'()*)+*,-./*0)1*%(2'$34'#(2.-)1*5*

633-(24#($+*7*-4*#8'$%9$3&+()*(+0.(#)*34'*-:8&34'(+)*

* ----oOo---- JURY : !

Président

:

Mme le Professeur Françoise DIGNAT-GEORGE

Membres :

M. le Professeur Pierre MORANGE

M. le Docteur Philippe PONCELET

"! !

! !

MÉMOIRE

DU DIPLÔME D’ÉTUDES SPECIALISÉES

DE BIOLOGIE MÉDICALE

! ! Soutenu le 09 octobre 2017 ! ! !

Par Mme FRITZ Shirley Né(e) le 09 mai 1989 !

Conformément aux dispositions du décret n°2003-76 du 23 janvier 2003, tenant lieu de !

! !

THÈSE

!

POUR LE DIPLÔME D’ÉTAT DE DOCTEUR EN

PHARMACIE

! ! ----oOo----

TITRE :

!"#$%&#'()*)+*,-./*0)1*%(2'$34'#(2.-)1*5*

633-(24#($+*7*-4*#8'$%9$3&+()*(+0.(#)*34'*-:8&34'(+)*

* ----oOo---- JURY : !

Président

:

Mme le Professeur Françoise DIGNAT-GEORGE

Membres :

M. le Professeur Pierre MORANGE

M. le Docteur Philippe PONCELET

- 1 - 27 Boulevard Jean Moulin – 13385 MARSEILLE Cedex 05

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Vice-Doyens : M. Jean-Paul BORG, M. Philippe CHARPIOT, M. Pascal RATHELOT

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PROFESSEURS

BIOPHYSIQUE M. Vincent PEYROT

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GENIE GENETIQUE ET BIOINGENIERIE M. Christophe DUBOIS

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- 2 - MAITRES DE CONFERENCES

BIOPHYSIQUE M. Robert GILLI

Mme Odile RIMET-GASPARINI Mme Pascale BARBIER

M. François DEVRED Mme Manon CARRE M. Gilles BREUZARD Mme Alessandra PAGANO

GENIE GENETIQUE ET BIOTECHNOLOGIE M. Eric SEREE-PACHA

Mme Véronique REY-BOURGAREL PHARMACIE GALENIQUE, PHARMACOTECHNIE INDUSTRIELLE,

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M. Pascal PRINDERRE M. Emmanuel CAUTURE Mme Véronique ANDRIEU Mme Marie-Pierre SAVELLI

NUTRITION ET DIETETIQUE M. Léopold TCHIAKPE

A.H.U.

CULTURE ET THERAPIE CELLULAIRE M. Jérémy MAGALON

ENSEIGNANTS CONTRACTUELS

ANGLAIS Mme Caroline MONTET

DEPARTEMENT BIOLOGIE PHARMACEUTIQUE

Responsable : Professeur Philippe CHARPIOT

PROFESSEURS

BIOCHIMIE FONDAMENTALE, MOLECULAIRE ET CLINIQUE M. Philippe CHARPIOT

BIOLOGIE CELLULAIRE M. Jean-Paul BORG

HEMATOLOGIE ET IMMUNOLOGIE Mme Françoise DIGNAT-GEORGE

Mme Laurence CAMOIN

Mme Florence SABATIER-MALATERRE

MICROBIOLOGIE M. Jean-Marc ROLAIN

M. Philippe COLSON PARASITOLOGIE ET MYCOLOGIE MEDICALE, HYGIENE ET

ZOOLOGIE

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BIOCHIMIE FONDAMENTALE, MOLECULAIRE ET CLINIQUE Mme Dominique JOURDHEUIL-RAHMANI

M. Thierry AUGIER M. Edouard LAMY

Mme Alexandrine BERTAUD Mme Claire CERINI

Mme Edwige TELLIER M. Stéphane POITEVIN

HEMATOLOGIE ET IMMUNOLOGIE Mme Nathalie BARDIN

Mme Dominique ARNOUX Mme Aurélie LEROYER M. Romaric LACROIX

MICROBIOLOGIE Mme Michèle LAGET

M. Michel DE MEO

Mme Anne DAVIN-REGLI Mme Véronique ROUX M. Fadi BITTAR

Mme Isabelle PAGNIER Mme Sophie EDOUARD PARASITOLOGIE ET MYCOLOGIE MEDICALE, HYGIENE ET

ZOOLOGIE

Mme Carole DI GIORGIO M. Aurélien DUMETRE Mme Magali CASANOVA Mme Anita COHEN

BIOLOGIE CELLULAIRE Mme Anne-Catherine LOUHMEAU

A.H.U.

HEMATOLOGIE ET IMMUNOLOGIE Mme Sylvie COINTE

DEPARTEMENT CHIMIE PHARMACEUTIQUE

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Mme Catherine BADENS CHIMIE PHYSIQUE – PREVENTION DES RISQUES ET

NUISANCES TECHNOLOGIQUES

M. Philippe GALLICE

CHIMIE MINERALE ET STRUCTURALE – CHIMIE THERAPEUTIQUE

M. Pascal RATHELOT M. Maxime CROZET

CHIMIE ORGANIQUE PHARMACEUTIQUE M. Patrice VANELLE

M. Thierry TERME PHARMACOGNOSIE, ETHNOPHARMACOLOGIE, HOMEOPATHIE Mme Evelyne OLLIVIER

- 4 - PROFESSEURS ASSOCIES A TEMPS PARTIEL (P.A.S.T.)

GESTION PHARMACEUTIQUE, PHARMACOECONOMIE ET ETHIQUE PHARMACEUTIQUE OFFICINALE

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MAITRES DE CONFERENCES

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Mme Joëlle MOULIN-TRAFFORT

CHIMIE ANALYTIQUE, QUALITOLOGIE ET NUTRITION Mme Elisabeth SCHREIBER-DETURMENY

Mme Catherine DEFOORT M. Alain NICOLAY

Mme Estelle WOLFF Mme Elise LOMBARD CHIMIE PHYSIQUE – PREVENTION DES RISQUES ET

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M. David BERGE-LEFRANC M. Pierre REBOUILLON

CHIMIE THERAPEUTIQUE Mme Catherine DIANA

Mme Sandrine FRANCO-ALIBERT Mme Caroline DUCROS

M. Marc MONTANA CHIMIE ORGANIQUE PHARMACEUTIQUE

HYDROLOGIE

M. Armand GELLIS M. Christophe CURTI Mme Julie BROGGI M. Nicolas PRIMAS M. Cédric SPITZ M. Sébastien REDON PHARMACOGNOSIE, ETHNOPHARMACOLOGIE, HOMEOPATHIE M. Riad ELIAS

Mme Valérie MAHIOU-LEDDET Mme Sok Siya BUN

Mme Béatrice BAGHDIKIAN

MAITRES DE CONFERENCE ASSOCIES A TEMPS PARTIEL (M.A.S.T.)

CHIMIE ANALYTIQUE, QUALITOLOGIE ET NUTRITION Mme Anne-Marie PENET-LOREC

CHIMIE PHYSIQUE – PREVENTION DES RISQUES ET NUISANCES TECHNOLOGIQUES

M. Thierry ATHUYT

DROIT ET ECONOMIE DE LA PHARMACIE M. Marc LAMBERT

DROIT ET COMMUNICATION PHARMACEUTIQUES A L’OFFICINE ET GESTION DE LA PHARMAFAC

M. Philippe BESSON

AHU

CHIMIE ORGANIQUE PHARMACEUTIQUE Mme Manon ROCHE

ATER

- 5 - DEPARTEMENT MEDICAMENT ET SECURITE SANITAIRE

Responsable : Professeur Benjamin GUILLET

PROFESSEURS

PHARMACIE CLINIQUE Mme Diane BRAGUER

PHARMACODYNAMIE M. Benjamin GUILLET

TOXICOCINETIQUE ET PHARMACOCINETIQUE M. Athanassios ILIADIS

TOXICOLOGIE GENERALE M. Bruno LACARELLE

TOXICOLOGIE DE L’ENVIRONNEMENT Mme Frédérique GRIMALDI

MAITRES DE CONFERENCES

PHARMACODYNAMIE Mme Suzanne MOUTERDE-MONJANEL

PHYSIOLOGIE Mme Sylviane LORTET

Mme Emmanuelle MANOS-SAMPOL

TOXICOCINETIQUE ET PHARMACOCINETIQUE M. Hot BUN

M. Joseph CICCOLINI

Mme Raphaëlle FANCIULLINO

TOXICOLOGIE GENERALE ET PHARMACIE CLINIQUE M. Pierre-Henri VILLARD

M. Stéphane HONORÉ

Mme Caroline SOLAS-CHESNEAU Mme Marie-Anne ESTEVE

A.H.U.

PHARMACODYNAMIE M. Philippe GARRIGUE

ATER

PHARMACODYNAMIE M. Guillaume HACHE

- 6 - CHARGES D’ENSEIGNEMENT A LA FACULTE

Mme Nathalie AUSIAS, Pharmacien-Praticien hospitalier M. Pierre BERTAULT-PERES, Pharmacien-Praticien hospitalier Mme Martine BUES-CHARBIT, Pharmacien-Praticien hospitalier M. Gérard CARLES, Pharmacien-Praticien hospitalier

Mme Nicole FRANCOIS, Pharmacien-Praticien hospitalier Mme Sophie GENSOLLEN, Pharmacien-Praticien hospitalier Mme Christine PENOT-RAGON, Pharmacien-Praticien hospitalier M. Stéphane PICHON, Pharmacien titulaire

M. Alain RAGON, Pharmacien-Praticien hospitalier

M. Badr Eddine TEHHANI, Pharmacien – Praticien hospitalier

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