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Novel insights into the role of fetal hemoglobin in spleen function, red cell survival and ineffective erythropoiesis in sickle cell disease

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Academic year: 2021

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Figure 3: Pathophysiology of Sickle Cell Disease. (A) Point mutation in SCD. (B) Polymerization of  hemoglobin  S  (HbS)  under  deoxygenation
Figure 5: Fetal and sickled hemoglobin. The predominant hemoglobin before birth is fetal hemoglobin  (HbF; α₂γ₂)
Figure 12: Timeline of Hydroxycarbmide in clinical studies for the treatment of sickle cell disease  (courtesy of Dr
Figure  14:  Scanning  electron  microscopy  micrograph  of  a  spleen  sample.  A  scanning  electron  microscopy from a spleen of 5-year-old boy with sickle cell anemia showing the tridimensional reticular  matrix of the red pulp (arrow)
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