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C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1

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Academic year: 2021

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Figure 1. CRP binds to MSU crystals. (a) Synovial fluid or serum from a patient with pseudogout was incubated with MSU crystals (lot 2) or zymosan for 45 min at 37 °C
Figure 2. MSU crystals specifically purify CRP (a) 200 µl of serum of a single donor with 1.5 µg/ml CRP (Serum1.5) with or without addition of 10 µg/ml purified CRP, a pool serum with 0.3 µg/ml CRP (pSerum0.3) with 10 µg/ml purified CRP added, a single
Figure 3. CRP recruits C1 and MASP1 to the surface of MSU crystals. (a) 40 µg/ml purified CRP or vehicle was added to serum and plasma (hirudin) from the same healthy male donor (CRP concentration of 0.7 µg/ ml)
Figure 4. CRP predominantly recognizes the edges or specific faces of MSU crystals. (a) MSU crystals (lot 2) were incubated for 30 min at 37 °C with human serum (CRP 0.2 µg/ml) with 30 µg/ml recombinant CRP added
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