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Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

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Academic year: 2021

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Figure 1. Endogenous AT1Rs and AT2Rs localize to the nucleus in canine atrial fibroblasts
Figure 2. AT1Rs and AT2Rs colocalize with TOPRO-3 nucleic-acid stain in canine atrial fibroblasts
Figure 3. Presence of G protein subunits in fibroblast nuclei. A, Detection of Gaq/11, Gai/3, Gas, and Gb in membrane, cytosolic, and nuclear fractions by immunoblot
Figure 4. Nuclear AT1Rs and AT2Rs regulate RNA synthesis in isolated atrial fibroblast nuclei; IP3R and NO are underlying mediators
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