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Botulinum toxin potentiates cancer radiotherapy and chemotherapy

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Academic year: 2021

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Fig. 1. Effect of a single i.t. injection of BoNT-A on FSAII tumor ( A ) and transplantable liver tumor ( B ) oxygenation monitored by EPR Oximetry
Fig. 2. A, typical MRI images of FSAII tumors showing the perfused pixels 3 days after treatment or vehicle
Fig. 4. Uptake of albumin-Evans blue in FSAII tumors. A nonsignificant increase is observed for treated groups (8.30 F 1.38, n = 4 versus 4.38 F 0.92 A g/g FSAII tumor, n = 4 for treated and control group, respectively)
Fig. 6. Effect of BoNT-A (0.73 units/100  10 6 cells) on FSAII cells evaluated by the trypan blue exclusion dye method ( A ) and by the clonogenic cell survival assay ( B )
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