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Dual function of ERR alpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.

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Academic year: 2021

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Table 1. Clinical and biological characteristics and ERR a mRNA expression in breast cancer patients
Figure 1. ERR a is a bad prognostic marker. Kaplan–Meier curves show correlation between high expression of ERRa, categorized with median value, and MFS in patients in (A) the whole population (N ¼ 251), (B) the ER-positive subset (N ¼ 209), (C and D) the
Figure 2. Modulation of ERRa in BO2 breast cancer cell line. A, ERRa protein expression (nucleus and cytoplasm) in BO2 cells by immunofluorescence and confocal microscopy and (B) in vivo by immunohistochemistry in bone metastasis present 30 days after intr
Figure 3. Overexpression of ERR a inhibits development of bone metastasis. A–C, BO2-ERRaWT-1, BO2-ERRaDAF2 (pool), or BO2-CT (pool) cells were inoculated into BALB/c nude mice; 35 days postinoculation, radiography revealed smaller osteolytic lesions in mic
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