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Prevalence of chronic kidney disease in Province of Liège: critical comparison with the American NHANES study?

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Deadline for receipt of abstracts: 15-02-2008

Name and address of corresponding author

Name: Pierre DELANAYE      

Institute: University of Liège, CHU Sart Tilman       Address: Service de Dialyse, CHU Sart Tilman       Post code: 4000     

City: Liège    

Telephone: 043667111      fax: 043667205      e-mail: pierre_delanaye@yahoo.fr      First author age < 35 years (born in 1973 or later): yes - no (please underline)

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ABSTRACT FORM

Annual Scientific Meeting of the BVN/SBN, Leuven, April 10 2008

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Instructions for authors:

1. Abstracts should be typed using single line spacing, Times 12 point font 2. Title: type in capitals

3. Authors: Type in lower case. Underline the name of the presenting author. Write only the surname in full, and use initials for the first name. At least one author must be a member of the SBN/BVN

4. Affiliation: type name of institute and city only. Use lower case 5. Body of the abstract: Organise the body of the abstract as follows:

a. State the purpose of the study b. Describe the methods

c. Summarize the results presented in sufficient details to support the conclusions d. Give the conclusions reached

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Abstracts should be sent by e-mail to: dialyse.brull@chu.ulg.ac.be before 15-02-2008 (receipt of your abstract will be acknowledged)

PREVALENCE OF CHRONIC KIDNEY DISEASE IN PROVINCE OF LIEGE: CRITICAL COMPARISON WITH THE AMERICAN NHANES STUDY

Delanaye P, Cavalier E, Saint-Remy A, Dechenne C, Krzesinski JM. University of Liège, CHU Liège Introduction: Prevalence of CKD is rising in Western countries. Early detection of CKD is of importance to delay its progression. In the USA, recent data from the NHANES study report that as much as 10.5% of the population has an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m².

Methods: People from the Province of Liège were voluntary proposed to estimate GFR. Between

September 2006 and January 2008, 3407 subjects were screened. Serum creatinine was measured with the IDMS traceable compensated Jaffé method (Roche diagnostics). The IDMS MDRD study equation was used to estimate GFR. Antecedents of the patients were also noted.

Results: In our population, we detect 9.8% of subjects with eGFR less than 60 ml/min/1.73 m². The prevalence of stage 3 CKD is thus comparable to a representative sample of the American population. Nevertheless, our population is not fully identical to the American population. Indeed, we screen our population on a voluntary basis and thus it may not be viewed as representative of the population of the province of Liège. So, the population from the Liège study was older (mean age: 61.3 ± 0.1 versus 44.8 ± 0.3 years old). If percentage of diabetics was comparable in both studies (± 10%), hypertension was more frequent in the Liège population (34.6 v 31.1%). Obesity (body mass index over 30 kg/m²) and percentage of black subjects more frequent in the American study (22.5 v 32.2% of obese).

Discussion and conclusion: Following our results and those from the NHANES study, ± 10 % of the population have stage 3 CKD. Nevertheless, eGFR is based on the results of the MDRD study equations. For these reason, both results from Liège and USA about stage 3 CKD prevalence are overestimated. Indeed, MDRD study equation has been built from a CKD population and underestimates real GFR because creatinine-GFR relationship is not the same in healthy and CKD patients. Moreover, the way of the new MDRD equation has been built to be IDMS traceable is questionable. The factor used in the new MDRD equation (175 versus 186 in the early equation) is too low, as we have recently demonstrated.

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