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Quality of the preoperative medication history for the patients scheduled for total hip replacement or total knee replacement at the CHU of Liege (QAMP-STUDY)


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© Acta Anæsthesiologica Belgica, 2014, 65, n° 3


ported by the patient to the pharmacist was 5.5 ± 3.8, in-creasing to 8.7 ± 4.5 by using specific questions or by contacting the patient’s community pharmacist. Informa-tion in the medical chart was incomplete for 486 drugs (53.5%). The discrepancies were : drug omission 61.9%, treatment schedule omission 13.8%, dose omission 10.3%, treatment schedule and dose omission 15.0%. Omitted drugs were mainly complementary and alterna-tive medicine products, analgesics and osteoporosis treatments, drugs for obstructive airway diseases, drugs for acids-related disorders, and cardiovascular system drugs (Table 1).


There were several errors in the medication history recorded preoperatively. This confirms the importance of improving the procedure for obtaining medication history. Education of anaesthesiologists, use of dedicated forms, collection of information from community phar-macists, active participation of a clinical pharmacist in the preoperative consultations or patient empowerment are suggested identified as possible ways of improve-ment.


1. Tam V. C., et al., cMaJ : canadian Medical aSSo -ciationJournal = Journaldel’aSSociation Medicale canadienne, 173, 510-515, 2005.

2. De Hert S., et al., europeanJournaloFanaeStHeSiol -ogy, 28, 684-722, 2011.

3. Whinney C., cleveland clinicJournaloFMedicine,

76 Suppl 4, S126-132, 2009. Introduction

Up to 27% of all hospital prescribing errors are re-lated to inaccurate medication history obtained upon ad-mission. Medication reconciliation is an important part of medication safety and a subject of growing interest. Few data are available about medication reconciliation at the preoperative visit for total hip replacement (THR) or total knee replacement (TKR). The objective of this study was to identify major errors existing in the preop-erative medication history with the aim to recommend a new standardized way to obtain a comprehensive medi-cation history for surgical patients at the preoperative visit.

Materials and Methods

The CHU of Liège is a teaching hospital of 925 beds. About 225 THR and TKR are performed each year. All patients are seen preoperatively by an anaesthesiologist. During this visit, the anaesthesiologist carries out a medication history. In a blinded prospective study con-ducted from December 2012 to June 2013, all elective THR or TKR patients were interviewed by a clinical pharmacist postoperatively. Patients were identified from the daily surgical list. The medication histories were col-lected by the clinical pharmacist using a standardized form and compared with the medication information ob-tained by the anaesthesiologist during the preoperative visit, reported in the medical record. The clinical impor-tance of theses discrepancies was evaluated as : level 0 : identified drug for which information on dose or treat-ment schedule is not important 38.7%, level 1 : discrep-ancy that doesn’t have any influence on perioperative management 40.3%, level 2 : discrepancy that can cause minor harm to patient 18.1%, level 3 : discrepancy that can cause moderate harm to patient 2.7% and level 4 : discrepancy that can cause severe or life threatening harm to patient 0.2%. These clinical relevance of the dis-crepancies were evaluated by anaesthesiologists after the data collection period. Discrepancies between anaesthe-siologist medication history record and the pharmacist were classified according to their type, origin, drugs and clinical importance.


With the approch of the local ethics commette and inform consent of the patient, 105 patients (60% of women, 57% of THR, with a mean age of 64 years) were enrolled in the study. The average number of drugs per patient reported by the anaesthesiologist was 5.8 ± 3.9 (mean ± SD), and the average number of drugs

self-re-Quality of the preoperative medication history for the patients scheduled for total hip replacement or

total knee replacement at the CHU of Liege (QAMP-STUDY). c. S


, a. b



b. r


, t. v




, J.F. b




Dpt. of Anesthesia and ICM,


Dpt. of Clinical Pharmacy,

CHU of Liège, University of Liège, Belgium.

Table 1

Top 10 most frequent discrepant drug

ATC Code Drug̓s name (INN) Total nb CAM products Phytotherapy, homeopathic and dietary

suplement products 60

N02BE01 Paracetamol 58

A11CC05 Colecalciferol 40

M01AE01 Ibuprofen 13

N02AX02 Tramadol 11

B01AC06 Acetylsalicylic acid 10

N02AX52 Tramadol, combinations (Zaldiar) 10

N05CF02 Zolpidem 10

H03AA01 Levothyroxine sodium 9

M02AA15 Diclofenac 8

Total 229

% (n = 486) 47.1


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