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Le genome leishmanien kinetoplastique

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Academic year: 2021

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Résumé du PFE : sous titre : Le génome leishmanien kinetoplastique

Résumé :

Le génome est un ensemble de matériel génétique, dont l’unité fonctionnelle est représentée par l’ADN. Toute modification de ce dernier, peut entraîner des changements assez impressionnants dans l’expression clinique d’une pathologie donnée. Dans le cas de la leishmaniose, le parasite responsable doit s’adapter à des conditions de vie différentes, son passage du vecteur à l’hôte, ou de l’hôte au vecteur, va entraîner des reprogrammations génétiques, provoquant ainsi des dysfonctionnements, à l’origine de certaines mutations génétiques et donc de nouvelles expressions cliniques de la pathologie.

Abstract :

The genome is a set of genetic material, whose unit is represented by DNA. Any modification of this last, may lead (pull) to changes quite impressive in the clinical expression of a given pathology.In the case of the leishmaniasis, the responsible parasite has to adapt himself to different living conditions, his passage from vector to host, or from host to vector, is going to pull genetic reprogrammations, so provoking dysfunctions, at the origin of certain geneti alterations , so , new clinical expressions of the pathology.

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